Utility of labile plasma iron and transferrin saturation in addition to serum ferritin as iron overload markers in different underlying anemias before and after deferasirox treatment

John B. Porter, Mohsen El-Alfy, Vip Viprakasit, Stephane Giraudier, Lee Lee Chan, Yongrong Lai, Ali El-Ali, Jackie Han, Maria D. Cappellini

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Plasma markers in addition to serum ferritin (SF) may be useful for the assessment of iron overload; however, predictive utility may differ depending on underlying, transfusion-dependent, anemias. Methods: Data were collected before and after 1year of deferasirox treatment (end of study; EOS) from the large, 1-year EPIC (Evaluation of Patients' Iron Chelation with Exjade®) study. Trends were evaluated between liver iron concentration (LIC), transferrin saturation (TfSat), predose labile plasma iron (LPI) and their relationship to SF categories in 1530 patients: thalassemia major (TM; n=1114), myelodysplastic syndromes (MDS, n=336), and sickle-cell disease (SCD, n=80). Results: Baseline and EOS SF values showed a clear and similar relationship to LIC for all disease groups. TfSat also showed a relationship to SF, most clearly in patients with SCD, where TfSat was lowest in the lowest relative SF category. Unlike SF or LIC, TfSat did not decrease at EOS in any disease group. Baseline LPI was raised in TM and MDS, but not in patients with SCD, decreasing at EOS in both patient groups. After 1year of chelation therapy, there was a significant trend for greater LPI reduction in patients with TM achieving LIC

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalEuropean Journal of Haematology
Volume96
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Keywords

  • Chelation therapy
  • Iron overload
  • Myelodysplastic syndromes
  • Sickle-cell disease
  • Thalassemia major

ASJC Scopus subject areas

  • Hematology

Fingerprint

Dive into the research topics of 'Utility of labile plasma iron and transferrin saturation in addition to serum ferritin as iron overload markers in different underlying anemias before and after deferasirox treatment'. Together they form a unique fingerprint.

Cite this