Vγ9Vδ2 T-cell anergy and complementarity-determining region 3-specific depletion during paroxysm of nonendemic malaria infection

Federico Martini, Maria Grazia Paglia, Carla Montesano, Patrick J. Enders, Marco Gentile, C. David Pauza, Cristiana Gioia, Vittorio Colizzi, Pasquale Narciso, Leopoldo Paolo Pucillo, Fabrizio Poccia

Research output: Contribution to journalArticle

Abstract

Vγ9Vδ2 T lymphocytes strongly respond to phosphoantigens from Plasmodium parasites. Thus, we analyzed the changes in Vγ9Vδ2 T-cell function and repertoire during the paroxysm phase of nonendemic malaria infection. During malaria paroxysm, Vγ9Vδ2 T cells were early activated but rapidly became anergic and finally loose Jγ1.2 Vγ9 complementarity-determining region 3 transcripts.

Original languageEnglish
Pages (from-to)2945-2949
Number of pages5
JournalInfection and Immunity
Volume71
Issue number5
DOIs
Publication statusPublished - May 1 2003

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Martini, F., Paglia, M. G., Montesano, C., Enders, P. J., Gentile, M., Pauza, C. D., Gioia, C., Colizzi, V., Narciso, P., Pucillo, L. P., & Poccia, F. (2003). Vγ9Vδ2 T-cell anergy and complementarity-determining region 3-specific depletion during paroxysm of nonendemic malaria infection. Infection and Immunity, 71(5), 2945-2949. https://doi.org/10.1128/IAI.71.5.2945-2949.2003