Vδ1+ gamma/delta T lymphocytes infiltrating human lung cancer express the CD8α/α homodimer

M. Ferrarini, S. Heltai, G. Chiesa, M. G. Sabbadini

Research output: Contribution to journalArticle

Abstract

Murine γ/δ T lymphocytes localize to different epithelial tissues and are phenotypically distinct from peripheral γ/δ T cell-populations in that they show limited TCR diversity, express the CD8 α/α homodimer and lack the CD8β chain. In humans, a compartmentalization of γ/δ cells sharing similar phenotypic features has been documented to date only in the case of intestinal epithelium. In the present study we show that about half of Vδ1+ (as well as Vδ1-Vδ2-) γ/δ lymphocytes, which can be selectively expanded from human lung cancers, coexpress the CD8α/α homodimer. The accumulation of intraepithelial CD8+ γ/δ+ lymphocytes might then be a more general phenomenon, possibly as a result of common mechanisms operating at those sites.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalScandinavian Journal of Immunology
Volume40
Issue number3
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Immunology

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