Vδ1 T lymphocytes producing IFN-γ and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans

Daniela Fenoglio, Alessandro Poggi, Silvia Catellani, Florinda Battaglia, Alessandra Ferrera, Maurizio Setti, Giuseppe Murdaca, Maria Raffaella Zocchi

Research output: Contribution to journalArticle

Abstract

In early HIV-1 infection, Vδ1 T lymphocytes are increased in peripheral blood and this is related to chemokine receptor expression, chemokine response, and recirculation. Herein we show that, at variance with healthy donors, in HIV-1-infected patients ex vivo-isolated Vδ1 T cells display cytoplasmic interferon-γ (IFN-γ). Interestingly, these cells coexpress cytoplasmic interleukin-17 (IL-17), and bear the CD27 surface marker of the memory T-cell subset. Vδ1 T cells, isolated from either patients or healthy donors, can proliferate and produce IFN-γ and IL-17 in response to Candida albicans in vitro, whereas Vδ2 T cells respond with proliferation and IFN-γ/IL-17 production to mycobacterial or phosphate antigens. These IFN-γ/IL-17 double-producer γδ T cells express the Th17 RORC and the Th1 TXB21 transcription factors and bear the CCR7 homing receptor and the CD161 molecule that are involved in γδ T-cell transendothelial migration. Moreover, Vδ1 T cells responding to C albicans express the chemokine receptors CCR4 and CCR6. This specifically equipped circulating memory γδ T-cell population might play an important role in the control of HIV-1 spreading and in the defense against opportunistic infections, possibly contributing to compensate for the impairment of CD4 + T cells.

Original languageEnglish
Pages (from-to)6611-6618
Number of pages8
JournalBlood
Volume113
Issue number26
DOIs
Publication statusPublished - 2009

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T-cells
Interleukin-17
Candida
Candida albicans
Interferons
HIV-1
T-Lymphocytes
Chemokine Receptors
CCR7 Receptors
Tissue Donors
Transendothelial and Transepithelial Migration
Data storage equipment
Opportunistic Infections
T-Lymphocyte Subsets
Chemokines
HIV Infections
Cell Movement
Transcription Factors
Phosphates
Blood

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Immunology
  • Hematology

Cite this

Vδ1 T lymphocytes producing IFN-γ and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. / Fenoglio, Daniela; Poggi, Alessandro; Catellani, Silvia; Battaglia, Florinda; Ferrera, Alessandra; Setti, Maurizio; Murdaca, Giuseppe; Zocchi, Maria Raffaella.

In: Blood, Vol. 113, No. 26, 2009, p. 6611-6618.

Research output: Contribution to journalArticle

Fenoglio, Daniela ; Poggi, Alessandro ; Catellani, Silvia ; Battaglia, Florinda ; Ferrera, Alessandra ; Setti, Maurizio ; Murdaca, Giuseppe ; Zocchi, Maria Raffaella. / Vδ1 T lymphocytes producing IFN-γ and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. In: Blood. 2009 ; Vol. 113, No. 26. pp. 6611-6618.
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