TY - JOUR
T1 - Vaccination and occurrence of seizures in SCN1A mutation-positive patients
T2 - A multicenter Italian study
AU - Zamponi, Nelia
AU - Passamonti, Claudia
AU - Petrelli, Cristina
AU - Veggiotti, Pierangelo
AU - Baldassari, Chiara
AU - Verrotti, Alberto
AU - Capovilla, Giovanni
AU - Viri, Maurizio
AU - Coppola, Giangennaro
AU - Vignoli, Aglaia
PY - 2014/3
Y1 - 2014/3
N2 - Background The relation between epileptic seizures and vaccinations is sometimes debated. In the present work, the impact of vaccination on seizure onset and clinical outcome of SCN1A mutation-positive patients is addressed. Methods Seventy-two patients diagnosed with Dravet syndrome or generalized epilepsy with febrile seizure plus, carrying SCN1A mutations or not, were included. Details on vaccination type, temporal relationship between vaccination and seizure occurrence, seizure type at onset and during development, cognitive functioning, and vaccination completion was obtained by reviewing clinical records. Patients were divided into two groups based on the temporal window between vaccination and seizure onset (proximate group: 48 hours). Results Vaccination-related seizures occurred in 25% of patients with SCN1A mutation and 18% of patients without the mutation (no significant difference). The proximate group showed an earlier age at seizure onset and a higher frequency of status epilepticus during development than did the distant group. No other significant differences were found. Subsequent vaccinations did not significantly alter the evolution of the disease. Conclusions Results from this relatively small series provide evidence that vaccinations do not significantly affect clinical and cognitive evolution of Dravet syndrome and generalized epilepsy with febrile seizure plus patients even if they carry SCN1A mutations.
AB - Background The relation between epileptic seizures and vaccinations is sometimes debated. In the present work, the impact of vaccination on seizure onset and clinical outcome of SCN1A mutation-positive patients is addressed. Methods Seventy-two patients diagnosed with Dravet syndrome or generalized epilepsy with febrile seizure plus, carrying SCN1A mutations or not, were included. Details on vaccination type, temporal relationship between vaccination and seizure occurrence, seizure type at onset and during development, cognitive functioning, and vaccination completion was obtained by reviewing clinical records. Patients were divided into two groups based on the temporal window between vaccination and seizure onset (proximate group: 48 hours). Results Vaccination-related seizures occurred in 25% of patients with SCN1A mutation and 18% of patients without the mutation (no significant difference). The proximate group showed an earlier age at seizure onset and a higher frequency of status epilepticus during development than did the distant group. No other significant differences were found. Subsequent vaccinations did not significantly alter the evolution of the disease. Conclusions Results from this relatively small series provide evidence that vaccinations do not significantly affect clinical and cognitive evolution of Dravet syndrome and generalized epilepsy with febrile seizure plus patients even if they carry SCN1A mutations.
KW - cognition
KW - Dravet syndrome
KW - GEFS+
KW - SCN1A gene
KW - seizure
KW - vaccination
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U2 - 10.1016/j.pediatrneurol.2013.09.016
DO - 10.1016/j.pediatrneurol.2013.09.016
M3 - Article
C2 - 24405698
AN - SCOPUS:84894048186
VL - 50
SP - 228
EP - 232
JO - Pediatric Neurology
JF - Pediatric Neurology
SN - 0887-8994
IS - 3
ER -