Vaccination and occurrence of seizures in SCN1A mutation-positive patients: A multicenter Italian study

Nelia Zamponi, Claudia Passamonti, Cristina Petrelli, Pierangelo Veggiotti, Chiara Baldassari, Alberto Verrotti, Giovanni Capovilla, Maurizio Viri, Giangennaro Coppola, Aglaia Vignoli

Research output: Contribution to journalArticlepeer-review


Background The relation between epileptic seizures and vaccinations is sometimes debated. In the present work, the impact of vaccination on seizure onset and clinical outcome of SCN1A mutation-positive patients is addressed. Methods Seventy-two patients diagnosed with Dravet syndrome or generalized epilepsy with febrile seizure plus, carrying SCN1A mutations or not, were included. Details on vaccination type, temporal relationship between vaccination and seizure occurrence, seizure type at onset and during development, cognitive functioning, and vaccination completion was obtained by reviewing clinical records. Patients were divided into two groups based on the temporal window between vaccination and seizure onset (proximate group: 48 hours). Results Vaccination-related seizures occurred in 25% of patients with SCN1A mutation and 18% of patients without the mutation (no significant difference). The proximate group showed an earlier age at seizure onset and a higher frequency of status epilepticus during development than did the distant group. No other significant differences were found. Subsequent vaccinations did not significantly alter the evolution of the disease. Conclusions Results from this relatively small series provide evidence that vaccinations do not significantly affect clinical and cognitive evolution of Dravet syndrome and generalized epilepsy with febrile seizure plus patients even if they carry SCN1A mutations.

Original languageEnglish
Pages (from-to)228-232
Number of pages5
JournalPediatric Neurology
Issue number3
Publication statusPublished - Mar 2014


  • cognition
  • Dravet syndrome
  • GEFS+
  • SCN1A gene
  • seizure
  • vaccination

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology


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