Vaccination coverage of patients with inborn errors of metabolism and the attitudes of their parents towards vaccines

Marta Cerutti, Pascale De Lonlay, Francesca Menni, Rossella Parini, Nicola Principi, Susanna Esposito

Research output: Contribution to journalArticle

Abstract

To evaluate vaccination coverage of children and adolescents with inborn errors of metabolism (IEMs) and the attitudes of their parents towards vaccination, the vaccination status of 128 patients with IEM and 128 age- and gender-matched healthy controls was established by consulting the official vaccination chart. In children with IEMs, compared with healthy controls, low vaccination rates and/or delays in administration were observed for pneumococcal conjugate, meningococcus C, measles, mumps, rubella, diphtheria-tetanus-pertussis-inactivated polio, Bacillus Calmette-Guerin, and influenza vaccines. Among the parents of IEM patients, vaccine schedule compliance was primarily driven by the doctors at the hospital's reference centres; among the parents of the healthy controls, compliance was driven by the primary care paediatricians. These results show that IEM patients demonstrate sub-optimal vaccination coverage. Further studies of the different vaccines in each IEM disorder and educational programmes aimed at physicians and parents to increase immunization coverage in these patients are urgently needed.

Original languageEnglish
Pages (from-to)6520-6524
Number of pages5
JournalVaccine
Volume33
Issue number48
DOIs
Publication statusPublished - Nov 27 2015

Keywords

  • Inborn errors of metabolism
  • Inherited metabolic diseases
  • Vaccination coverage
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

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