Vaccination in human solid tumors: Recent progress in the clinical arena

Giorgio Parmiani; Carolina Cimminiello; Cristina Maccalli; Vincenzo Russo

doi:10.1007/978-3-662-46410-6_2

Vaccination in human solid tumors: Recent progress in the clinical arena

Giorgio Parmiani, Carolina Cimminiello, Cristina Maccalli, Vincenzo Russo

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.

Original language	English
Title of host publication	Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors
Publisher	Springer Berlin Heidelberg
Pages	41-46
Number of pages	6
ISBN (Print)	9783662464106, 9783662464090
DOIs	https://doi.org/10.1007/978-3-662-46410-6_2
Publication status	Published - Jan 1 2015

Keywords

Progression
Solid tumors
Vaccination

ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)

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10.1007/978-3-662-46410-6_2

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AU - Maccalli, Cristina

AU - Russo, Vincenzo

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AB - Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.

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KW - Vaccination

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Vaccination in human solid tumors: Recent progress in the clinical arena

Abstract

Keywords

ASJC Scopus subject areas

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