Vaccination in human solid tumors: Recent progress in the clinical arena

Giorgio Parmiani, Carolina Cimminiello, Cristina Maccalli, Vincenzo Russo

Research output: Chapter in Book/Report/Conference proceedingChapter


Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.

Original languageEnglish
Title of host publicationCancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors
PublisherSpringer Berlin Heidelberg
Number of pages6
ISBN (Print)9783662464106, 9783662464090
Publication statusPublished - Jan 1 2015


  • Progression
  • Solid tumors
  • Vaccination

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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