Vaccination in human solid tumors: Recent progress in the clinical arena

Giorgio Parmiani, Carolina Cimminiello, Cristina Maccalli, Vincenzo Russo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Studies in animal models showed that antitumor immune response can be induced by a variety of cancer vaccines. This may also occur in the clinic, but the immune response in vaccinated cancer patients was rarely associated with a significant clinical response. This chapter will discuss (a) the crucial issue of the most appropriate tumor antigens (self vs. mutated) to be used for vaccination in human solid tumors; (b) the different factors that may impair antitumor immune response; (c) the reasons for the last, successful wave of vaccination trials; and (d) the role of combined vaccination and immunomodulation in the treatment of solid tumors.

Original languageEnglish
Title of host publicationCancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors
PublisherSpringer Berlin Heidelberg
Pages41-46
Number of pages6
ISBN (Print)9783662464106, 9783662464090
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Progression
  • Solid tumors
  • Vaccination

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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  • Cite this

    Parmiani, G., Cimminiello, C., Maccalli, C., & Russo, V. (2015). Vaccination in human solid tumors: Recent progress in the clinical arena. In Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors (pp. 41-46). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-662-46410-6_2