Vaccination of pregnant cynomolgus monkeys with whole formalin-inactivated SIVmac251.

F. Titti, A. Borsetti, A. Geraci, L. Sernicola, L. Giuseppini, G. P. Turillazzi, M. Pace, S. Baroncelli, A. Amadori, A. Giovannetti

Research output: Contribution to journalArticlepeer-review

Abstract

Five pregnant (two to three and one-half months) Macaca fascicularis seroconverted following immunization with sucrose-gradient purified and formalin-inactivated whole simian immunodeficiency virus (SIVmac251). No untoward effects on fetal maturation were observed during the immunization of the mothers. Antibodies to SIVmac251 (also those with in vitro neutralizing activity) were passively transferred to the offspring but disappeared within two to six months after birth. Antibodies to env glycoprotein (gp130) lasted longer than those against viral gag proteins (p26,p60).

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalJournal of Medical Primatology
Volume21
Issue number2-3
Publication statusPublished - Feb 1992

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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