Vaccine administration in children with chronic kidney disease

Susanna Esposito, Maria Vincenza Mastrolia, Elisabetta Prada, Carlo Pietrasanta, Nicola Principi

Research output: Contribution to journalArticlepeer-review

Abstract

Pediatric patients with severe chronic kidney disease (CKD) on conservative treatment, on dialysis, and those with renal transplantation are at a higher risk for infectious diseases as the result of impaired immune responses against infectious agents. Infections in these patients can have drastic consequences for disease morbidity and mortality. Immunization is a crucial preventive strategy for disease management in this pediatric population. However, vaccination coverage among children with CKD remains low due to safety concerns and doubts about vaccine immunogenicity and efficacy. In this study, we reviewed why children with CKD are at higher risk of infections, the importance of vaccinations among these children, barriers to vaccinations, and recommend the best vaccination schedules. Overall, vaccines have acceptable immunogenicity, efficacy, and safety profiles in children with CKD. However, in some cases, the protective antibody levels induced by vaccines and the benefits and risks of booster vaccine doses must be individually managed. Furthermore, close contacts and household members of these children should complete age-appropriate vaccination schedules to increase the child's indirect protection.

Original languageEnglish
Pages (from-to)6601-6606
Number of pages6
JournalVaccine
Volume32
Issue number49
DOIs
Publication statusPublished - 2014

Keywords

  • Chronic kidney disease
  • Dialysis
  • Renal transplantation
  • Vaccination
  • Vaccines

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine
  • Medicine(all)

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