Vaccine effectiveness against severe laboratory-confirmed influenza in children: Results of two consecutive seasons in Italy

Francesca Menniti-Ippolito, Roberto Da Cas, Giuseppe Traversa, Carmela Santuccio, Patrizia Felicetti, Loriana Tartaglia, Francesco Trotta, Pasquale Di Pietro, Paola Barabino, Salvatore Renna, Laura Riceputi, Pier Angelo Tovo, Clara Gabiano, Antonio Urbino, Luca Baroero, Daniele Le Serre, Silvia Virano, Giorgio Perilongo, Marco Daverio, Elisa GnoatoMichela Maretti, Beatrice Galeazzo, Giulia Rubin, Stefania Scanferla, Liviana Da Dalt, Chiara Stefani, Claudia Zerbinati, Elena Chiappini, Sara Sollai, Maurizio De Martino, Francesco Mannelli, Sabrina Becciani, Martina Giacalone, Simona Montano, Giulia Remaschi, Alessia Stival, Mario Furbetta, Piera Abate, Ilaria Leonardi, Nicola Pirozzi, Umberto Raucci, Antonino Reale, Rossella Rossi, Cristina Russo, Livia Mancinelli, Onori Manuela, Concato Carlo, Nadia Mores, Costantino Romagnoli, Antonio Chiaretti, Adele Compagnone, Riccardo Riccardi, Giovanni Delogu, Michela Sali, Valentina Prete, Vincenzo Tipo, Michele Dinardo, Fabiana Auricchio, Teodoro Polimeno, Giuseppe Sodano, Alessandra Maccariello, Concita Rafaniello, Fortunata Fucà, Eleonora Di Rosa, Domenica Altavilla, Anna Mecchio, Teresa Arrigo

Research output: Contribution to journalArticle

Abstract

•Vaccine effectiveness in children visiting an Emergency Department for influenza.•Test negative case-control study in 11 paediatric centres in two influenza seasons.•Vaccine effectiveness in preventing ED visits: 38% (95% CI -52% to 75%).•Add information for recommendation for vaccination in children. Objective: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. Methods: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. Results: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4%) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38% (95% confidence interval -52% to 75%). A higher VE was estimated for hospitalised children (53%; 95% confidence interval -45% to 85%). Discussion: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children.

Original languageEnglish
Pages (from-to)4466-4470
Number of pages5
JournalVaccine
Volume32
Issue number35
DOIs
Publication statusPublished - Jul 31 2014

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influenza
Human Influenza
Italy
Vaccines
vaccines
Hospital Emergency Service
confidence interval
Influenza Vaccines
Confidence Intervals
case-control studies
physicians
Case-Control Studies
Vaccination
Hospitalization
vaccination
Pediatric Hospitals
Hospitalized Child
Centers for Disease Control and Prevention (U.S.)
Orthomyxoviridae
testing

Keywords

  • Case-control study
  • Children
  • Influenza vaccine effectiveness
  • Laboratory-confirmed cases

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine
  • Medicine(all)

Cite this

Menniti-Ippolito, F., Da Cas, R., Traversa, G., Santuccio, C., Felicetti, P., Tartaglia, L., ... Arrigo, T. (2014). Vaccine effectiveness against severe laboratory-confirmed influenza in children: Results of two consecutive seasons in Italy. Vaccine, 32(35), 4466-4470. https://doi.org/10.1016/j.vaccine.2014.06.048

Vaccine effectiveness against severe laboratory-confirmed influenza in children : Results of two consecutive seasons in Italy. / Menniti-Ippolito, Francesca; Da Cas, Roberto; Traversa, Giuseppe; Santuccio, Carmela; Felicetti, Patrizia; Tartaglia, Loriana; Trotta, Francesco; Di Pietro, Pasquale; Barabino, Paola; Renna, Salvatore; Riceputi, Laura; Tovo, Pier Angelo; Gabiano, Clara; Urbino, Antonio; Baroero, Luca; Le Serre, Daniele; Virano, Silvia; Perilongo, Giorgio; Daverio, Marco; Gnoato, Elisa; Maretti, Michela; Galeazzo, Beatrice; Rubin, Giulia; Scanferla, Stefania; Da Dalt, Liviana; Stefani, Chiara; Zerbinati, Claudia; Chiappini, Elena; Sollai, Sara; De Martino, Maurizio; Mannelli, Francesco; Becciani, Sabrina; Giacalone, Martina; Montano, Simona; Remaschi, Giulia; Stival, Alessia; Furbetta, Mario; Abate, Piera; Leonardi, Ilaria; Pirozzi, Nicola; Raucci, Umberto; Reale, Antonino; Rossi, Rossella; Russo, Cristina; Mancinelli, Livia; Manuela, Onori; Carlo, Concato; Mores, Nadia; Romagnoli, Costantino; Chiaretti, Antonio; Compagnone, Adele; Riccardi, Riccardo; Delogu, Giovanni; Sali, Michela; Prete, Valentina; Tipo, Vincenzo; Dinardo, Michele; Auricchio, Fabiana; Polimeno, Teodoro; Sodano, Giuseppe; Maccariello, Alessandra; Rafaniello, Concita; Fucà, Fortunata; Di Rosa, Eleonora; Altavilla, Domenica; Mecchio, Anna; Arrigo, Teresa.

In: Vaccine, Vol. 32, No. 35, 31.07.2014, p. 4466-4470.

Research output: Contribution to journalArticle

Menniti-Ippolito, F, Da Cas, R, Traversa, G, Santuccio, C, Felicetti, P, Tartaglia, L, Trotta, F, Di Pietro, P, Barabino, P, Renna, S, Riceputi, L, Tovo, PA, Gabiano, C, Urbino, A, Baroero, L, Le Serre, D, Virano, S, Perilongo, G, Daverio, M, Gnoato, E, Maretti, M, Galeazzo, B, Rubin, G, Scanferla, S, Da Dalt, L, Stefani, C, Zerbinati, C, Chiappini, E, Sollai, S, De Martino, M, Mannelli, F, Becciani, S, Giacalone, M, Montano, S, Remaschi, G, Stival, A, Furbetta, M, Abate, P, Leonardi, I, Pirozzi, N, Raucci, U, Reale, A, Rossi, R, Russo, C, Mancinelli, L, Manuela, O, Carlo, C, Mores, N, Romagnoli, C, Chiaretti, A, Compagnone, A, Riccardi, R, Delogu, G, Sali, M, Prete, V, Tipo, V, Dinardo, M, Auricchio, F, Polimeno, T, Sodano, G, Maccariello, A, Rafaniello, C, Fucà, F, Di Rosa, E, Altavilla, D, Mecchio, A & Arrigo, T 2014, 'Vaccine effectiveness against severe laboratory-confirmed influenza in children: Results of two consecutive seasons in Italy', Vaccine, vol. 32, no. 35, pp. 4466-4470. https://doi.org/10.1016/j.vaccine.2014.06.048
Menniti-Ippolito F, Da Cas R, Traversa G, Santuccio C, Felicetti P, Tartaglia L et al. Vaccine effectiveness against severe laboratory-confirmed influenza in children: Results of two consecutive seasons in Italy. Vaccine. 2014 Jul 31;32(35):4466-4470. https://doi.org/10.1016/j.vaccine.2014.06.048
Menniti-Ippolito, Francesca ; Da Cas, Roberto ; Traversa, Giuseppe ; Santuccio, Carmela ; Felicetti, Patrizia ; Tartaglia, Loriana ; Trotta, Francesco ; Di Pietro, Pasquale ; Barabino, Paola ; Renna, Salvatore ; Riceputi, Laura ; Tovo, Pier Angelo ; Gabiano, Clara ; Urbino, Antonio ; Baroero, Luca ; Le Serre, Daniele ; Virano, Silvia ; Perilongo, Giorgio ; Daverio, Marco ; Gnoato, Elisa ; Maretti, Michela ; Galeazzo, Beatrice ; Rubin, Giulia ; Scanferla, Stefania ; Da Dalt, Liviana ; Stefani, Chiara ; Zerbinati, Claudia ; Chiappini, Elena ; Sollai, Sara ; De Martino, Maurizio ; Mannelli, Francesco ; Becciani, Sabrina ; Giacalone, Martina ; Montano, Simona ; Remaschi, Giulia ; Stival, Alessia ; Furbetta, Mario ; Abate, Piera ; Leonardi, Ilaria ; Pirozzi, Nicola ; Raucci, Umberto ; Reale, Antonino ; Rossi, Rossella ; Russo, Cristina ; Mancinelli, Livia ; Manuela, Onori ; Carlo, Concato ; Mores, Nadia ; Romagnoli, Costantino ; Chiaretti, Antonio ; Compagnone, Adele ; Riccardi, Riccardo ; Delogu, Giovanni ; Sali, Michela ; Prete, Valentina ; Tipo, Vincenzo ; Dinardo, Michele ; Auricchio, Fabiana ; Polimeno, Teodoro ; Sodano, Giuseppe ; Maccariello, Alessandra ; Rafaniello, Concita ; Fucà, Fortunata ; Di Rosa, Eleonora ; Altavilla, Domenica ; Mecchio, Anna ; Arrigo, Teresa. / Vaccine effectiveness against severe laboratory-confirmed influenza in children : Results of two consecutive seasons in Italy. In: Vaccine. 2014 ; Vol. 32, No. 35. pp. 4466-4470.
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abstract = "•Vaccine effectiveness in children visiting an Emergency Department for influenza.•Test negative case-control study in 11 paediatric centres in two influenza seasons.•Vaccine effectiveness in preventing ED visits: 38{\%} (95{\%} CI -52{\%} to 75{\%}).•Add information for recommendation for vaccination in children. Objective: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. Methods: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. Results: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4{\%}) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38{\%} (95{\%} confidence interval -52{\%} to 75{\%}). A higher VE was estimated for hospitalised children (53{\%}; 95{\%} confidence interval -45{\%} to 85{\%}). Discussion: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children.",
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T1 - Vaccine effectiveness against severe laboratory-confirmed influenza in children

T2 - Results of two consecutive seasons in Italy

AU - Menniti-Ippolito, Francesca

AU - Da Cas, Roberto

AU - Traversa, Giuseppe

AU - Santuccio, Carmela

AU - Felicetti, Patrizia

AU - Tartaglia, Loriana

AU - Trotta, Francesco

AU - Di Pietro, Pasquale

AU - Barabino, Paola

AU - Renna, Salvatore

AU - Riceputi, Laura

AU - Tovo, Pier Angelo

AU - Gabiano, Clara

AU - Urbino, Antonio

AU - Baroero, Luca

AU - Le Serre, Daniele

AU - Virano, Silvia

AU - Perilongo, Giorgio

AU - Daverio, Marco

AU - Gnoato, Elisa

AU - Maretti, Michela

AU - Galeazzo, Beatrice

AU - Rubin, Giulia

AU - Scanferla, Stefania

AU - Da Dalt, Liviana

AU - Stefani, Chiara

AU - Zerbinati, Claudia

AU - Chiappini, Elena

AU - Sollai, Sara

AU - De Martino, Maurizio

AU - Mannelli, Francesco

AU - Becciani, Sabrina

AU - Giacalone, Martina

AU - Montano, Simona

AU - Remaschi, Giulia

AU - Stival, Alessia

AU - Furbetta, Mario

AU - Abate, Piera

AU - Leonardi, Ilaria

AU - Pirozzi, Nicola

AU - Raucci, Umberto

AU - Reale, Antonino

AU - Rossi, Rossella

AU - Russo, Cristina

AU - Mancinelli, Livia

AU - Manuela, Onori

AU - Carlo, Concato

AU - Mores, Nadia

AU - Romagnoli, Costantino

AU - Chiaretti, Antonio

AU - Compagnone, Adele

AU - Riccardi, Riccardo

AU - Delogu, Giovanni

AU - Sali, Michela

AU - Prete, Valentina

AU - Tipo, Vincenzo

AU - Dinardo, Michele

AU - Auricchio, Fabiana

AU - Polimeno, Teodoro

AU - Sodano, Giuseppe

AU - Maccariello, Alessandra

AU - Rafaniello, Concita

AU - Fucà, Fortunata

AU - Di Rosa, Eleonora

AU - Altavilla, Domenica

AU - Mecchio, Anna

AU - Arrigo, Teresa

PY - 2014/7/31

Y1 - 2014/7/31

N2 - •Vaccine effectiveness in children visiting an Emergency Department for influenza.•Test negative case-control study in 11 paediatric centres in two influenza seasons.•Vaccine effectiveness in preventing ED visits: 38% (95% CI -52% to 75%).•Add information for recommendation for vaccination in children. Objective: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. Methods: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. Results: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4%) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38% (95% confidence interval -52% to 75%). A higher VE was estimated for hospitalised children (53%; 95% confidence interval -45% to 85%). Discussion: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children.

AB - •Vaccine effectiveness in children visiting an Emergency Department for influenza.•Test negative case-control study in 11 paediatric centres in two influenza seasons.•Vaccine effectiveness in preventing ED visits: 38% (95% CI -52% to 75%).•Add information for recommendation for vaccination in children. Objective: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. Methods: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. Results: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4%) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38% (95% confidence interval -52% to 75%). A higher VE was estimated for hospitalised children (53%; 95% confidence interval -45% to 85%). Discussion: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children.

KW - Case-control study

KW - Children

KW - Influenza vaccine effectiveness

KW - Laboratory-confirmed cases

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