Vaccines and febrile seizures

Nicola Principi, Susanna Esposito

Research output: Contribution to journalArticlepeer-review

Abstract

Vaccine administration is the second leading cause of febrile seizures (FS). FS occurrence in children is a serious concern because it leads to public apprehension of vaccinations. This review discusses the clinical implications of FS, its potential link to vaccinations and its impact on official recommendations for vaccinations in children. Vaccines such as the pertussis antigen-containing vaccine, the measles-containing vaccine and the influenza vaccine have been linked to FS. However, FS events are very rare and are not usually associated with downstream complications or severe neurologic diseases. Considering their significant health benefits, vaccinations have not been restricted in the pediatric population. Nevertheless, vaccine-induced FS could be a problem, particularly in genetically predisposed children. Therefore, post-marketing surveillance studies are required to accurately assess the incidence of FS and identify individuals who are particularly susceptible to FS after vaccination.

Original languageEnglish
Pages (from-to)885-892
Number of pages8
JournalExpert Review of Vaccines
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2013

Keywords

  • febrile seizures
  • influenza vaccine
  • measles-containing vaccines
  • pertussis vaccines
  • prevention
  • vaccines
  • varicella vaccine

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

Fingerprint

Dive into the research topics of 'Vaccines and febrile seizures'. Together they form a unique fingerprint.

Cite this