Vaccines and Kawasaki disease

Susanna Esposito, Sonia Bianchini, Rosa Maria Dellepiane, Nicola Principi

Research output: Contribution to journalArticlepeer-review

Abstract

The distinctive immune system characteristics of children with Kawasaki disease (KD) could suggest that they respond in a particular way to all antigenic stimulations, including those due to vaccines. Moreover, treatment of KD is mainly based on immunomodulatory therapy. These factors suggest that vaccines and KD may interact in several ways. These interactions could be of clinical relevance because KD is a disease of younger children who receive most of the vaccines recommended for infectious disease prevention. This paper shows that available evidence does not support an association between KD development and vaccine administration. Moreover, it highlights that administration of routine vaccines is mandatory even in children with KD and all efforts must be made to ensure the highest degree of protection against vaccine-preventable diseases for these patients. However, studies are needed to clarify currently unsolved issues, especially issues related to immunologic interference induced by intravenous immunoglobulin and biological drugs.

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalExpert Review of Vaccines
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 3 2016

Keywords

  • Aspirin
  • biological drugs
  • immunosuppressive therapy
  • intravenous immunoglobulin
  • Kawasaki disease

ASJC Scopus subject areas

  • Immunology
  • Drug Discovery
  • Pharmacology
  • Molecular Medicine

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