Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant ΔV2 Env

Barbara Ensoli, Aurelio Cafaro, Antonella Caputo, Valeria Fiorelli, Fabrizio Ensoli, Riccardo Gavioli, Flavia Ferrantelli, Andrea Cara, Fausto Titti, Mauro Magnani

Research output: Contribution to journalArticle

Abstract

The promising results obtained with the HIV-1 Tat-based vaccines in mice, monkeys and humans, a better understanding of Tat immunomodulatory functions, as well as evidence that vaccination with trimeric V2 loop-deleted HIV-1 Env induces cross-clade neutralizing antibodies led to the rational design of a novel vaccine based on the combination of Tat and V2-deleted Env.

Original languageEnglish
Pages (from-to)1392-1399
Number of pages8
JournalMicrobes and Infection
Volume7
Issue number14
DOIs
Publication statusPublished - Nov 2005

Keywords

  • ΔV2 Env protein
  • HIV/AIDS vaccine
  • Tat protein

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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    Ensoli, B., Cafaro, A., Caputo, A., Fiorelli, V., Ensoli, F., Gavioli, R., Ferrantelli, F., Cara, A., Titti, F., & Magnani, M. (2005). Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant ΔV2 Env. Microbes and Infection, 7(14), 1392-1399. https://doi.org/10.1016/j.micinf.2005.07.016