Abstract
A significant series of experimental and clinical studies have demonstrated the close association between reduced vagal reflexes (baroreflex sensitivity, BRS) and increased sudden and non-sudden cardiovascular mortality. Subsequently, evidence was provided that, also among chronic heart failure (HF) patients, depressed BRS is associated with a poorer outcome. At the same time, the encouraging results with experimental and clinical attempts to increase cardiac vagal activity led to a few experimental studies with vagal stimulation (VS) in different models for HF. We first performed a pilot study for VS in HF patients, and then in 2011 we reported the results of a small size multicentre clinical trial. The 6-month and 1-year results are encouraging for feasibility, safety and appear to have a favourable clinical effect. An ongoing large clinical trial will provide a definitive assessment of the efficacy and usefulness of chronic VS in HF patients.
| Original language | English |
|---|---|
| Pages (from-to) | 82-84 |
| Number of pages | 3 |
| Journal | Netherlands Heart Journal |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2013 |
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Keywords
- Autonomic nervous system
- Baroreflex sensitivity
- Heart failure
- Vagal stimulation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Vagal stimulation for heart diseases : From animals to men. An example of translational cardiology. / Schwartz, P. J.
In: Netherlands Heart Journal, Vol. 21, No. 2, 02.2013, p. 82-84.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vagal stimulation for heart diseases
T2 - From animals to men. An example of translational cardiology
AU - Schwartz, P. J.
PY - 2013/2
Y1 - 2013/2
N2 - A significant series of experimental and clinical studies have demonstrated the close association between reduced vagal reflexes (baroreflex sensitivity, BRS) and increased sudden and non-sudden cardiovascular mortality. Subsequently, evidence was provided that, also among chronic heart failure (HF) patients, depressed BRS is associated with a poorer outcome. At the same time, the encouraging results with experimental and clinical attempts to increase cardiac vagal activity led to a few experimental studies with vagal stimulation (VS) in different models for HF. We first performed a pilot study for VS in HF patients, and then in 2011 we reported the results of a small size multicentre clinical trial. The 6-month and 1-year results are encouraging for feasibility, safety and appear to have a favourable clinical effect. An ongoing large clinical trial will provide a definitive assessment of the efficacy and usefulness of chronic VS in HF patients.
AB - A significant series of experimental and clinical studies have demonstrated the close association between reduced vagal reflexes (baroreflex sensitivity, BRS) and increased sudden and non-sudden cardiovascular mortality. Subsequently, evidence was provided that, also among chronic heart failure (HF) patients, depressed BRS is associated with a poorer outcome. At the same time, the encouraging results with experimental and clinical attempts to increase cardiac vagal activity led to a few experimental studies with vagal stimulation (VS) in different models for HF. We first performed a pilot study for VS in HF patients, and then in 2011 we reported the results of a small size multicentre clinical trial. The 6-month and 1-year results are encouraging for feasibility, safety and appear to have a favourable clinical effect. An ongoing large clinical trial will provide a definitive assessment of the efficacy and usefulness of chronic VS in HF patients.
KW - Autonomic nervous system
KW - Baroreflex sensitivity
KW - Heart failure
KW - Vagal stimulation
UR - http://www.scopus.com/inward/record.url?scp=84875203948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875203948&partnerID=8YFLogxK
U2 - 10.1007/s12471-012-0368-5
DO - 10.1007/s12471-012-0368-5
M3 - Article
C2 - 23250848
AN - SCOPUS:84875203948
VL - 21
SP - 82
EP - 84
JO - Netherlands Heart Journal
JF - Netherlands Heart Journal
SN - 1568-5888
IS - 2
ER -