Vagal stimulation in heart failure

Research output: Contribution to journalArticlepeer-review

Abstract

Heart failure (HF) is accompanied by an autonomic imbalance that is almost always characterized by both increased sympathetic activity and withdrawal of vagal activity. Experimentally, vagal stimulation has been shown to exert profound antiarrhythmic activity and to improve cardiac function and survival in HF models. A open-label pilot clinical study in 32 patients with chronic HF has shown safety and tolerability of chronic vagal stimulation associated with subjective (improved quality of life and 6-min walk test) and objective improvements (reduced left ventricular systolic volumes and improved left ventricular ejection fraction). Three larger clinical studies, including a phase III trial are currently ongoing and will evaluate the clinical role of this new approach.

Original languageEnglish
Pages (from-to)310-320
Number of pages11
JournalJournal of Cardiovascular Translational Research
Volume7
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Anti-inflammatory activity
  • Heart failure
  • Reperfusion damage
  • Vagal activity
  • Vagus nerve stimulation
  • Ventricular fibrillation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Genetics
  • Genetics(clinical)
  • Molecular Medicine
  • Pharmaceutical Science
  • Medicine(all)

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