Vagal system impairment in human immunodeficiency virus-positive patients with chronic hepatitis C: Does hepatic glutathione deficiency have a pathogenetic role?

G. Barbaro, G. D I Di Lorenzo, M. Soldini, G. Bellomo, G. Belloni, B. Grisorio, G. Barbarini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Both an autonomic impairment and a systemic depletion of reduced glutathione (GSH) may be documented in patients with chronic liver diseases and in human immunodeficiency virus (HIV)-positive patients. Methods: The coefficients of electrocardiographic R-R interval variation (CVc) were assessed in 125 patients with chronic hepatitis C (CHC) (65 HIV- positive and 60 HIV-negative) and in 61 healthy controls. The CVc values were correlated with hepatic (H-GSH), plasmatic (P-GSH), lymphocyte (L-GSH), and erythrocyte (E-GSH) concentrations of GSH and with erythrocyte malonyldialdehyde (MDA) levels. Results: Compared with healthy controls, in CHC patients the concentrations of H-GSH, P-GSH, L-GSH, and E-GSH were reduced, whereas MDA levels were increased with a statistically significant difference (P <0.001). CVc was significantly reduced in patients with CHC (especially in those who were HIV-positive) and correlated significantly with the values of H-GSH, P-GSH; L-GSH, E-GSH, and MDA (P <0.001). Conclusions: A dysfunction of the cardiac vagal system may be detected in patients with CHC (especially in those who are HIV-positive); this abnormality may be related to a reduced response to oxidative stress because of a systemic depletion of GSH.

Original languageEnglish
Pages (from-to)1261-1266
Number of pages6
JournalScandinavian Journal of Gastroenterology
Volume32
Issue number12
Publication statusPublished - 1997

Keywords

  • Autonomic system
  • Chronic hepatitis C
  • Hepatitis C virus
  • Human immunodeficiency virus
  • R-R interval variation
  • Reduced glutathione

ASJC Scopus subject areas

  • Gastroenterology

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