Vagal Withdrawal and Susceptibility to Cardiac Arrhythmias in Rats with High Trait Aggressiveness

Luca Carnevali, Mimosa Trombini, Alberto Porta, Nicola Montano, Sietse F. de Boer, Andrea Sgoifo

Research output: Contribution to journalArticle

Abstract

Personality characteristics, e.g. aggressiveness, have long been associated with an increased risk of cardiac disease. However, the underlying mechanisms remain unclear. In this study we used a rodent model for characterizing cardiac autonomic modulation in rats that differ widely in their level of aggressive behavior. To reach this goal, high-aggressive (HA, n = 10) and non-aggressive (NA, n = 10) rats were selected from a population (n = 121) of adult male Wild-type Groningen rats on the basis of their latency time to attack (ALT, s) a male intruder in a resident-intruder test lasting 600 s. In order to obtain information on their cardiac autonomic modulation, ECG recordings were subsequently obtained via radiotelemetry at rest, during stressful stimuli and under autonomic pharmacological manipulations, and analyzed by means of time- and frequency-domain indexes of heart rate variability. During resting conditions, HA rats (ALT600 s). Exposure to stressful stimuli (i.e. restraint and psychosocial stress) provoked similar tachycardic responses between the two groups. However, under stress conditions HA rats displayed a reduced vagal antagonism and an increased incidence of tachyarrhythmias compared to NA rats. In addition, beta-adrenergic pharmacological stimulation induced a much larger incidence of ventricular tachyarrhythmias in HA rats compared to NA counterparts. These findings are consistent with the view that high levels of aggressive behavior in rats are associated to signs of cardiac autonomic impairment and increased arrhythmogenic susceptibility that may predict vulnerability to cardiac morbidity and mortality.

Original languageEnglish
Article numbere68316
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 4 2013

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arrhythmia
Rats
Cardiac Arrhythmias
aggression
rats
Tachycardia
Modulation
Pharmacology
incidence
Incidence
heart diseases
radio telemetry
Electrocardiography
Adrenergic Agents
morbidity
Personality
heart rate
Rodentia
Heart Diseases
Netherlands

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Vagal Withdrawal and Susceptibility to Cardiac Arrhythmias in Rats with High Trait Aggressiveness. / Carnevali, Luca; Trombini, Mimosa; Porta, Alberto; Montano, Nicola; de Boer, Sietse F.; Sgoifo, Andrea.

In: PLoS One, Vol. 8, No. 7, e68316, 04.07.2013.

Research output: Contribution to journalArticle

Carnevali, Luca ; Trombini, Mimosa ; Porta, Alberto ; Montano, Nicola ; de Boer, Sietse F. ; Sgoifo, Andrea. / Vagal Withdrawal and Susceptibility to Cardiac Arrhythmias in Rats with High Trait Aggressiveness. In: PLoS One. 2013 ; Vol. 8, No. 7.
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