Abstract
Objective: To evaluate the effectiveness and tolerance of vaginal cabergoline in hyperprolactinemic patients intolerant to oral dopaminergics. Design: Case reports. Setting: University hospital endocrinological outpatient clinic. Patients: A 35-year-old primipara woman with idiopathic hyperprolactinemia and a 22-year-old female with primary amenorrhea harboring macroprolactinoma. Interventions: Treatment with vaginal cabergoline (0.5 mg two and five times a week). Main Outcome Measures: The serum PRL levels and side effects were assessed before and during treatment. Results: A single vaginal dose of 0.5 mg cabergoline reduced serum PRL levels by approximately 50% to 85% of basal values over a period of 4 to 5 hours. In the patient with idiopathic hyperprolactinemia, serum PRL levels normalized during long-term treatment, whereas in the one with macroprolactinoma they remained above the normal values (79 ng/mL [conversion factor to SI unit, 3.180]) despite resumption of menses and marked tumor shrinkage (70% reduction). No side effects were reported. Conclusions: Vaginal cabergoline is a safe and effective method of therapy for hyperprolactinemia and it avoids the adverse events of oral administration.
Original language | English |
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Pages (from-to) | 440-442 |
Number of pages | 3 |
Journal | Fertility and Sterility |
Volume | 65 |
Issue number | 2 |
Publication status | Published - 1996 |
Keywords
- bromocriptine
- Cabergoline
- macroprolactinoma
- MRI
ASJC Scopus subject areas
- Obstetrics and Gynaecology