Vaginal lactoferrin administration before genetic amniocentesis decreases amniotic interleukin-6 levels

Fortunato Vesce, Emilio Giugliano, Stefania Bignardi, Elisa Cagnazzo, Cecilia Colamussi, Roberto Marci, Nicoletta Valente, Silvia Seraceni, Martina Maritati, Carlo Contini

Research output: Contribution to journalArticlepeer-review


Aim: To verify the eventual efficacy of lactoferrin (LF), an iron-binding glycoprotein, to decrease the amniotic concentration of interleukin-6 (IL-6). Methods: We prospectively enrolled 60 Caucasian patients at the 16th week of their singleton physiological gestation. A vaginal compound containing 300 mg of LF was administered randomly 4 or 12 h prior to amniocentesis, as to obtain 3 groups: A, 20 untreated patients; B, 20 treated 4 h before amniocentesis; C, 20 treated 12 h before amniocentesis. Results: A normal karyotype was registered in all cases. The comparison of the distribution of IL-6 among the 3 groups showed a highly significant difference (p = 0.001). The difference between mean values of group B and both groups C and A was shown to be highly significant (p = 0.006 and p = 0.03, respectively). In contrast, there was no significant difference between mean values of groups A and C. Conclusion: Vaginal LF administration decreases amniotic IL-6 concentration. We therefore suggest that the glycoprotein may exert a protective role against ominous pregnancy complications linked to an increased level of the cytokine, such as abortion secondary to amniocentesis.

Original languageEnglish
Pages (from-to)245-249
Number of pages5
JournalGynecologic and Obstetric Investigation
Issue number4
Publication statusPublished - 2014


  • Abortion
  • Amniocentesis
  • Interleukin-6
  • Lactoferrin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)


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