Vagus nerve stimulation in treatment-resistant depression: Acute and follow-up results of an italian case series

Bernardo Dell'Osso, Lucio Oldani, M. Carlotta Palazzo, Ilaria Balossi, Mariateresa Ciabatti, A. Carlo Altamura

Research output: Contribution to journalArticlepeer-review

Abstract

The present study evaluated short-and long-term efficacy and tolerability of augmentative vagus nerve stimulation (VNS) in a group of patients with treatment-resistant depression (N = 6). A statistically significant improvement in the Hamilton Depression Rating Scale (HDRS21) and Montgomery-Asberg Depression Rating Scale after 3 months (P = 0.039 and P = 0.05, respectively) was found in comparison with baseline (VNS implant). After 12 months, a statistically significant improvement was observed in the Hamilton Depression Rating Scale (HDRS21), Montgomery-Asberg Depression Rating Scale, and Clinical Global Impression (P = 0.01, P = 0.005, and P = 0.001, respectively). Patients showed an overall favorable tolerability. Present data support VNS short-and long-term efficacy and tolerability in a small group of patients with treatment-resistant depression. Further controlled investigation is necessary to confirm the present open findings.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalJournal of ECT
Volume29
Issue number1
DOIs
Publication statusPublished - Mar 2013

Keywords

  • short-and long-term efficacy
  • tolerability
  • treatment-resistant depression
  • vagus nerve stimulation

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience (miscellaneous)

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