Vagus nerve stimulation therapy in treatment-resistant depression: A series report

Giuseppe Tisi, Angelo Franzini, Giuseppe Messina, Mario Savino, Orsola Gambini

Research output: Contribution to journalArticlepeer-review

Abstract

Aim The purpose of this study was to evaluate the efficacy of vagus nerve stimulation (VNS) as a therapeutic option for treatment-resistant depression (TRD), with follow-up periods of 1, 3 and 5 years after VNS surgery. Methods We examined 27 consecutive patients with unipolar TRD. Depressive symptoms were evaluated both at baseline and at follow-up after the surgery by means of the 21-item Hamilton Rating Scale for Depression (HAM-D 21). Results The mean HAM-D preoperative score was 25.6. Twenty-two patients were evaluated after 1 year of treatment, and the mean improvement of the HAM-D score was of 10.3. Five patients (20%) went into complete remission (HAM-D

Original languageEnglish
Pages (from-to)606-611
Number of pages6
JournalPsychiatry and Clinical Neurosciences
Volume68
Issue number8
DOIs
Publication statusPublished - 2014

Keywords

  • Hamilton Rating Scale for Depression
  • long-term follow up
  • remission
  • treatment-resistant depression
  • vagus nerve stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Medicine(all)

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