Vagus nerve stimulation therapy in treatment-resistant depression: A series report

Giuseppe Tisi, Angelo Franzini, Giuseppe Messina, Mario Savino, Orsola Gambini

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim The purpose of this study was to evaluate the efficacy of vagus nerve stimulation (VNS) as a therapeutic option for treatment-resistant depression (TRD), with follow-up periods of 1, 3 and 5 years after VNS surgery. Methods We examined 27 consecutive patients with unipolar TRD. Depressive symptoms were evaluated both at baseline and at follow-up after the surgery by means of the 21-item Hamilton Rating Scale for Depression (HAM-D 21). Results The mean HAM-D preoperative score was 25.6. Twenty-two patients were evaluated after 1 year of treatment, and the mean improvement of the HAM-D score was of 10.3. Five patients (20%) went into complete remission (HAM-D

Original languageEnglish
Pages (from-to)606-611
Number of pages6
JournalPsychiatry and Clinical Neurosciences
Volume68
Issue number8
DOIs
Publication statusPublished - 2014

Fingerprint

Treatment-Resistant Depressive Disorder
Vagus Nerve Stimulation
Depression
Therapeutics

Keywords

  • Hamilton Rating Scale for Depression
  • long-term follow up
  • remission
  • treatment-resistant depression
  • vagus nerve stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Medicine(all)

Cite this

Vagus nerve stimulation therapy in treatment-resistant depression : A series report. / Tisi, Giuseppe; Franzini, Angelo; Messina, Giuseppe; Savino, Mario; Gambini, Orsola.

In: Psychiatry and Clinical Neurosciences, Vol. 68, No. 8, 2014, p. 606-611.

Research output: Contribution to journalArticle

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