TY - JOUR
T1 - Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC
AU - Asti, Mattia
AU - De Pietri, Giovanni
AU - Fraternali, Alessandro
AU - Grassi, Elisa
AU - Sghedoni, Roberto
AU - Fioroni, Federica
AU - Roesch, Frank
AU - Versari, Annibale
AU - Salvo, Diana
PY - 2008/8
Y1 - 2008/8
N2 - Introduction: Imaging of somatostatin receptor expressing tumours has been greatly enhanced by the use of 68Ga-DOTATOC and PET/CT. Methods: In this work, a purification method for the 68Ge/68Ga generator eluate and a method to produce 68Ga-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the 68Ga solution was investigated by ICP-MS. The radiotracer quality was evaluated by radio-TLC, GC and γ-ray spectrometry. Results: 68Ga-DOTATOC preparations (n=33) were carried out with a mean synthesis yield of 59.3±2.8% (not corrected for decay) and a batch activity ranging from 555 to 296 MBq. The radiochemical and radionuclidic purity were >98% and 99.9999%, respectively. With this purification process, >95% of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution. Conclusions: 68Ga-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations.
AB - Introduction: Imaging of somatostatin receptor expressing tumours has been greatly enhanced by the use of 68Ga-DOTATOC and PET/CT. Methods: In this work, a purification method for the 68Ge/68Ga generator eluate and a method to produce 68Ga-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the 68Ga solution was investigated by ICP-MS. The radiotracer quality was evaluated by radio-TLC, GC and γ-ray spectrometry. Results: 68Ga-DOTATOC preparations (n=33) were carried out with a mean synthesis yield of 59.3±2.8% (not corrected for decay) and a batch activity ranging from 555 to 296 MBq. The radiochemical and radionuclidic purity were >98% and 99.9999%, respectively. With this purification process, >95% of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution. Conclusions: 68Ga-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations.
KW - Ge/Ga generator
KW - Cation-exchange chromatography
KW - DOTATOC
KW - PET
KW - Postprocessing of eluates
UR - http://www.scopus.com/inward/record.url?scp=48349142477&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=48349142477&partnerID=8YFLogxK
U2 - 10.1016/j.nucmedbio.2008.04.006
DO - 10.1016/j.nucmedbio.2008.04.006
M3 - Article
C2 - 18678358
AN - SCOPUS:48349142477
VL - 35
SP - 721
EP - 724
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 6
ER -