Validation of 68Ge/68Ga generator processing by chemical purification for routine clinical application of 68Ga-DOTATOC

Mattia Asti, Giovanni De Pietri, Alessandro Fraternali, Elisa Grassi, Roberto Sghedoni, Federica Fioroni, Frank Roesch, Annibale Versari, Diana Salvo

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Imaging of somatostatin receptor expressing tumours has been greatly enhanced by the use of 68Ga-DOTATOC and PET/CT. Methods: In this work, a purification method for the 68Ge/68Ga generator eluate and a method to produce 68Ga-DOTATOC suitable for clinical use were evaluated. The generator eluate was purified and concentrated on a cation-exchange cartridge in HCl/acetone media. The efficacy of this procedure in eliminating metal impurities from the 68Ga solution was investigated by ICP-MS. The radiotracer quality was evaluated by radio-TLC, GC and γ-ray spectrometry. Results: 68Ga-DOTATOC preparations (n=33) were carried out with a mean synthesis yield of 59.3±2.8% (not corrected for decay) and a batch activity ranging from 555 to 296 MBq. The radiochemical and radionuclidic purity were >98% and 99.9999%, respectively. With this purification process, >95% of the Fe(III), Zn(II) and Mn(II) were eliminated from the solution. Conclusions: 68Ga-DOTATOC produced with this method can be efficiently used in nuclear medicine departments for PET evaluations.

Original languageEnglish
Pages (from-to)721-724
Number of pages4
JournalNuclear Medicine and Biology
Volume35
Issue number6
DOIs
Publication statusPublished - Aug 2008

Keywords

  • Ge/Ga generator
  • Cation-exchange chromatography
  • DOTATOC
  • PET
  • Postprocessing of eluates

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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