Validation of a cardiopulmonary exercise test score in heart failure

Jonathan Myers, Ricardo Oliveira, Frederick Dewey, Ross Arena, Marco Guazzi, Paul Chase, Daniel Bensimhon, Mary Ann Peberdy, Euan Ashley, Erin West, Lawrence P. Cahalin, Daniel E. Forman

Research output: Contribution to journalArticlepeer-review

Abstract

Background-Cardiopulmonary exercise test (CPX) responses are strong predictors of outcomes in patients with heart failure. We recently developed a CPX score that integrated the additive prognostic information from CPX. The purpose of this study was to validate the score in a larger, independent sample of patients. Methods and Results-A total of 2625 patients with heart failure underwent CPX and were followed for cardiovascular (CV) mortality and major CV events (death, transplantation, left ventricular assist device implantation). Net reclassification improvement (NRI) for the score and each of its components were determined at 3 years. The VE/VCO2 slope was the strongest predictor of risk and was attributed a relative weight of 7, with weighted scores for abnormal heart rate recovery, oxygen uptake efficiency slope, end-tidal CO2 pressure, and peak VO2 having scores of 5, 3, 3, and 2, respectively. A summed score of >15 was associated with an annual mortality rate of 12.2% and a relative risk >9 for total events, whereas a score of

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalCirculation: Heart Failure
Volume6
Issue number2
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Epidemiology
  • Exercise physiology
  • Exercise testing
  • Heart failure
  • Oxygen consumption

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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