Validation of a computerised measurement system for guided routine evaluation of cardiovascular autonomic neuropathy

Giacomo Vespasiani, Mauro Bruni, Illidio Meloncelli, Lina Clementi, Rita Amoretti, Salvatore Branca, F. Carinci, Stanislao Lostia, A. Nicolucci, Fabio Romagnoli, Salvatore Verga, Massimo Massi Benedetti

Research output: Contribution to journalArticlepeer-review


A study for evaluating the use of the Cardionomic system was conducted in six Italian Centres for Diabetes. Cardionomic is a portable computerised system that is used for a guided step-by-step performance of several cardiovascular tests for autonomic neuropathy (heart rate and blood pressure). It has been compared to the traditional method using an electrocardiograph. In this study, which involved 74 diabetic patients, 392 cardiovascular tests were conducted with the electrocardiograph and 392 were done using the portable system. The results were compared to the results obtained with the ECG assuming the latter as the standard ones. All the indices of validity that were investigated (sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio) indicate that the proposed system is reliable. Because it saves a considerable amount of time and is also easy to use, it represents a valid alternative for the routine screening of autonomic neuropathy.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalComputer Methods and Programs in Biomedicine
Issue number3
Publication statusPublished - Nov 1996


  • Cardiovascular autonomic function tests
  • Cardiovascular autonomic neuropathy
  • Diabetes mellitus
  • Portable computerised system

ASJC Scopus subject areas

  • Software


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