Validation of a new hand function outcome measure in individuals with Charcot-Marie-Tooth disease

Valeria Prada, Giulia Robbiano, Giulia Mennella, Mehrnaz Hamedani, Emilia Bellone, Marina Grandis, Angelo Schenone, Riccardo Zuccarino

Research output: Contribution to journalArticlepeer-review


The symptomatology of Charcot-Marie-Tooth (CMT) disease mainly involves the feet and the hands. To date, there is no consensus on how to evaluate hand function in CMT. The aim of this study is to correlate the data of the engineered glove Hand Test System (HTS) with specific tests and the CMT examination score (CMTES). We analyzed 45 patients with the diagnosis of CMT using HTS, which measures the hand dexterity by specific sequences performed at maximum velocity. We completed the evaluation with the CMTES, tripod pinch and hand grip strength tested by a dynamometer, thumb opposition test (TOT), and Sollerman Hand function test (SHFT), and we conducted a test-retest with 20 normal subjects. Finger tapping (FT) and index-medium-ring-little (IMRL) sequence showed a significant correlation with CMTES (FT: dominant hand (DH): P =.036; non-dominant hand (NDH): P =.033; IMRL: DH: P =.009; NDH: P =.046). TOT correlated with CMTES significantly in both hands (P <.0001). tripod pinch showed a statistically significant correlation with CMTES (DH: P =.002; NDH: P =.005). Correlation between the hand grip and CMTES was significant only in DH (DH: P =.002). SHFT had a significant correlation with the CMTES (DH: P =.002). Test-retest showed a good reliability. HTS parameters correlate with CMTES confirming that this tool is sensitive to the hand deficits. In conclusion, we can state that HTS is a good, simple to use, and objective instrument to evaluate the hand function of CMT patients, but more studies on responsiveness and sensitivity are needed.

Original languageEnglish
JournalJournal of the Peripheral Nervous System
Publication statusAccepted/In press - 2020


  • Charcot-Marie-Tooth
  • engineered glove
  • hand function
  • neuropathies
  • outcome measures

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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