Validation of a patient-specific hemodynamic computational model for surgical planning of vascular access in hemodialysis patients

Anna Caroli, Simone Manini, Luca Antiga, Katia Passera, Bogdan Ene-Iordache, Stefano Rota, Giuseppe Remuzzi, Aron Bode, Jaap Leermakers, Frans N. Van De Vosse, Raymond Vanholder, Marko Malovrh, Jan Tordoir, Andrea Remuzzi, A. Remuzzi, J. H M Tordoir, A. S. Bode, Aldo E Cele Dacco, A. Remuzzi, L. AntigaA. Caroli, S. Manini, K. Passera, L. Botti, J. H M Tordoir, A. S. Bode, M. Hameeteman, J. J P M Leermakers, R. N. Planken, T. Leiner, W. Huberts, M. Merkx, W. Kroon, E. M H Bosboom, F. N. Van De Vosse, K. Van Canneyt, L. Araujo, P. Verdonck, P. Segers, M. Malovrh, A. Narracott, M. Bayley, M. Breeuwer, J. Olivan-Bescos, W. Van Der linden, M. Alves De Inda, P. Brands

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Vascular access dysfunction is one of the main causes of morbidity and hospitalization in hemodialysis patients. This major clinical problem points out the need for prediction of hemodynamic changes induced by vascular access surgery. Here we reviewed the potential of a patient-specific computational vascular network model that includes vessel wall remodeling to predict blood flow change within 6 weeks after surgery for different arteriovenous fistula configurations. For model validation, we performed a multicenter, prospective clinical study to collect longitudinal data on arm vasculature before and after surgery. Sixty-three patients with newly created arteriovenous fistula were included in the validation data set and divided into four groups based on fistula configuration. Predicted brachial artery blood flow volumes 40 days after surgery had a significantly high correlation with measured values. Deviation of predicted from measured brachial artery blood flow averaged 3% with a root mean squared error of 19.5%, showing that the computational tool reliably predicted patient-specific blood flow increase resulting from vascular access surgery and subsequent vascular adaptation. This innovative approach may help the surgeon to plan the most appropriate fistula configuration to optimize access blood flow for hemodialysis, potentially reducing the incidence of vascular access dysfunctions and the need of patient hospitalization.

Original languageEnglish
Pages (from-to)1237-1245
Number of pages9
JournalKidney International
Volume84
Issue number6
DOIs
Publication statusPublished - Dec 1 2013

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Anatomic Models
Blood Vessels
Renal Dialysis
Hemodynamics
Brachial Artery
Arteriovenous Fistula
Fistula
Hospitalization
Blood Volume
Ambulatory Surgical Procedures
Prospective Studies
Morbidity
Incidence

Keywords

  • access blood flow
  • hemodialysis access
  • vascular access

ASJC Scopus subject areas

  • Nephrology

Cite this

Validation of a patient-specific hemodynamic computational model for surgical planning of vascular access in hemodialysis patients. / Caroli, Anna; Manini, Simone; Antiga, Luca; Passera, Katia; Ene-Iordache, Bogdan; Rota, Stefano; Remuzzi, Giuseppe; Bode, Aron; Leermakers, Jaap; Van De Vosse, Frans N.; Vanholder, Raymond; Malovrh, Marko; Tordoir, Jan; Remuzzi, Andrea; Remuzzi, A.; Tordoir, J. H M; Bode, A. S.; Dacco, Aldo E Cele; Remuzzi, A.; Antiga, L.; Caroli, A.; Manini, S.; Passera, K.; Botti, L.; Tordoir, J. H M; Bode, A. S.; Hameeteman, M.; Leermakers, J. J P M; Planken, R. N.; Leiner, T.; Huberts, W.; Merkx, M.; Kroon, W.; Bosboom, E. M H; Van De Vosse, F. N.; Van Canneyt, K.; Araujo, L.; Verdonck, P.; Segers, P.; Malovrh, M.; Narracott, A.; Bayley, M.; Breeuwer, M.; Olivan-Bescos, J.; Van Der linden, W.; Alves De Inda, M.; Brands, P.

In: Kidney International, Vol. 84, No. 6, 01.12.2013, p. 1237-1245.

Research output: Contribution to journalArticle

Caroli, A, Manini, S, Antiga, L, Passera, K, Ene-Iordache, B, Rota, S, Remuzzi, G, Bode, A, Leermakers, J, Van De Vosse, FN, Vanholder, R, Malovrh, M, Tordoir, J, Remuzzi, A, Remuzzi, A, Tordoir, JHM, Bode, AS, Dacco, AEC, Remuzzi, A, Antiga, L, Caroli, A, Manini, S, Passera, K, Botti, L, Tordoir, JHM, Bode, AS, Hameeteman, M, Leermakers, JJPM, Planken, RN, Leiner, T, Huberts, W, Merkx, M, Kroon, W, Bosboom, EMH, Van De Vosse, FN, Van Canneyt, K, Araujo, L, Verdonck, P, Segers, P, Malovrh, M, Narracott, A, Bayley, M, Breeuwer, M, Olivan-Bescos, J, Van Der linden, W, Alves De Inda, M & Brands, P 2013, 'Validation of a patient-specific hemodynamic computational model for surgical planning of vascular access in hemodialysis patients', Kidney International, vol. 84, no. 6, pp. 1237-1245. https://doi.org/10.1038/ki.2013.188
Caroli, Anna ; Manini, Simone ; Antiga, Luca ; Passera, Katia ; Ene-Iordache, Bogdan ; Rota, Stefano ; Remuzzi, Giuseppe ; Bode, Aron ; Leermakers, Jaap ; Van De Vosse, Frans N. ; Vanholder, Raymond ; Malovrh, Marko ; Tordoir, Jan ; Remuzzi, Andrea ; Remuzzi, A. ; Tordoir, J. H M ; Bode, A. S. ; Dacco, Aldo E Cele ; Remuzzi, A. ; Antiga, L. ; Caroli, A. ; Manini, S. ; Passera, K. ; Botti, L. ; Tordoir, J. H M ; Bode, A. S. ; Hameeteman, M. ; Leermakers, J. J P M ; Planken, R. N. ; Leiner, T. ; Huberts, W. ; Merkx, M. ; Kroon, W. ; Bosboom, E. M H ; Van De Vosse, F. N. ; Van Canneyt, K. ; Araujo, L. ; Verdonck, P. ; Segers, P. ; Malovrh, M. ; Narracott, A. ; Bayley, M. ; Breeuwer, M. ; Olivan-Bescos, J. ; Van Der linden, W. ; Alves De Inda, M. ; Brands, P. / Validation of a patient-specific hemodynamic computational model for surgical planning of vascular access in hemodialysis patients. In: Kidney International. 2013 ; Vol. 84, No. 6. pp. 1237-1245.
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AU - Manini, Simone

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AU - Ene-Iordache, Bogdan

AU - Rota, Stefano

AU - Remuzzi, Giuseppe

AU - Bode, Aron

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AU - Van De Vosse, Frans N.

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AU - Bode, A. S.

AU - Hameeteman, M.

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