Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients

Gábor Cserni, Simonetta Bianchi, Vania Vezzosi, Riccardo Arisio, Johannes L. Peterse, Anna Sapino, Isabella Castellano, Maria Drijkoningen, Janina Kulka, Vincenzo Eusebi, Maria P. Foschini, Jean Pierre Bellocq, Cristi Marin, Sten Thorstenson, Isabel Amendoeira, Angelika Reiner-Concin, Thomas Decker, Manuela Lacerda, Paulo Figueiredo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Two recently developed clinical prediction rules aim to anticipate the lack of nonsentinel lymph node metastases and the involvement of less than 4 lymph nodes in breast cancer patients with positive sentinel lymph nodes (SLNs). Methods: The University of Louisville Breast SLN Study clinical prediction rules were validated on an independent set of SLN-positive patients with tumors ≤15 mm. Results: The data on 475 and 473 patients, respectively, were used for the validation. The areas under the receiver operating characteristic curves were similar to the originals for both predictive tools (.70 and .76). The lowest score of 1 identified 5 of 7 patients with disease limited to the SLNs and 161 of 165 as having less than 4 involved lymph nodes. Conclusions: A subset of patients with SLN-only involvement and less than 4 metastatic lymph nodes can probably be identified by means of the Louisville clinical prediction rules, but prediction of the lack of non-SLN metastasis seems less reliable.

Original languageEnglish
Pages (from-to)288-293
Number of pages6
JournalAmerican Journal of Surgery
Volume194
Issue number3
DOIs
Publication statusPublished - Sep 2007

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Decision Support Techniques
Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
ROC Curve
Breast
Sentinel Lymph Node
Neoplasms

Keywords

  • Breast cancer
  • Clinical prediction rules
  • Nonsentinel lymph nodes
  • Postmastectomy radiation therapy
  • Sentinel lymph nodes
  • T1 tumors

ASJC Scopus subject areas

  • Surgery

Cite this

Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients. / Cserni, Gábor; Bianchi, Simonetta; Vezzosi, Vania; Arisio, Riccardo; Peterse, Johannes L.; Sapino, Anna; Castellano, Isabella; Drijkoningen, Maria; Kulka, Janina; Eusebi, Vincenzo; Foschini, Maria P.; Bellocq, Jean Pierre; Marin, Cristi; Thorstenson, Sten; Amendoeira, Isabel; Reiner-Concin, Angelika; Decker, Thomas; Lacerda, Manuela; Figueiredo, Paulo.

In: American Journal of Surgery, Vol. 194, No. 3, 09.2007, p. 288-293.

Research output: Contribution to journalArticle

Cserni, G, Bianchi, S, Vezzosi, V, Arisio, R, Peterse, JL, Sapino, A, Castellano, I, Drijkoningen, M, Kulka, J, Eusebi, V, Foschini, MP, Bellocq, JP, Marin, C, Thorstenson, S, Amendoeira, I, Reiner-Concin, A, Decker, T, Lacerda, M & Figueiredo, P 2007, 'Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients', American Journal of Surgery, vol. 194, no. 3, pp. 288-293. https://doi.org/10.1016/j.amjsurg.2007.02.014
Cserni, Gábor ; Bianchi, Simonetta ; Vezzosi, Vania ; Arisio, Riccardo ; Peterse, Johannes L. ; Sapino, Anna ; Castellano, Isabella ; Drijkoningen, Maria ; Kulka, Janina ; Eusebi, Vincenzo ; Foschini, Maria P. ; Bellocq, Jean Pierre ; Marin, Cristi ; Thorstenson, Sten ; Amendoeira, Isabel ; Reiner-Concin, Angelika ; Decker, Thomas ; Lacerda, Manuela ; Figueiredo, Paulo. / Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients. In: American Journal of Surgery. 2007 ; Vol. 194, No. 3. pp. 288-293.
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