Abstract
Background: Two recently developed clinical prediction rules aim to anticipate the lack of nonsentinel lymph node metastases and the involvement of less than 4 lymph nodes in breast cancer patients with positive sentinel lymph nodes (SLNs). Methods: The University of Louisville Breast SLN Study clinical prediction rules were validated on an independent set of SLN-positive patients with tumors ≤15 mm. Results: The data on 475 and 473 patients, respectively, were used for the validation. The areas under the receiver operating characteristic curves were similar to the originals for both predictive tools (.70 and .76). The lowest score of 1 identified 5 of 7 patients with disease limited to the SLNs and 161 of 165 as having less than 4 involved lymph nodes. Conclusions: A subset of patients with SLN-only involvement and less than 4 metastatic lymph nodes can probably be identified by means of the Louisville clinical prediction rules, but prediction of the lack of non-SLN metastasis seems less reliable.
| Original language | English |
|---|---|
| Pages (from-to) | 288-293 |
| Number of pages | 6 |
| Journal | American Journal of Surgery |
| Volume | 194 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 2007 |
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Keywords
- Breast cancer
- Clinical prediction rules
- Nonsentinel lymph nodes
- Postmastectomy radiation therapy
- Sentinel lymph nodes
- T1 tumors
ASJC Scopus subject areas
- Surgery
Cite this
Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients. / Cserni, Gábor; Bianchi, Simonetta; Vezzosi, Vania; Arisio, Riccardo; Peterse, Johannes L.; Sapino, Anna; Castellano, Isabella; Drijkoningen, Maria; Kulka, Janina; Eusebi, Vincenzo; Foschini, Maria P.; Bellocq, Jean Pierre; Marin, Cristi; Thorstenson, Sten; Amendoeira, Isabel; Reiner-Concin, Angelika; Decker, Thomas; Lacerda, Manuela; Figueiredo, Paulo.
In: American Journal of Surgery, Vol. 194, No. 3, 09.2007, p. 288-293.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validation of clinical prediction rules for a low probability of nonsentinel and extensive lymph node involvement in breast cancer patients
AU - Cserni, Gábor
AU - Bianchi, Simonetta
AU - Vezzosi, Vania
AU - Arisio, Riccardo
AU - Peterse, Johannes L.
AU - Sapino, Anna
AU - Castellano, Isabella
AU - Drijkoningen, Maria
AU - Kulka, Janina
AU - Eusebi, Vincenzo
AU - Foschini, Maria P.
AU - Bellocq, Jean Pierre
AU - Marin, Cristi
AU - Thorstenson, Sten
AU - Amendoeira, Isabel
AU - Reiner-Concin, Angelika
AU - Decker, Thomas
AU - Lacerda, Manuela
AU - Figueiredo, Paulo
PY - 2007/9
Y1 - 2007/9
N2 - Background: Two recently developed clinical prediction rules aim to anticipate the lack of nonsentinel lymph node metastases and the involvement of less than 4 lymph nodes in breast cancer patients with positive sentinel lymph nodes (SLNs). Methods: The University of Louisville Breast SLN Study clinical prediction rules were validated on an independent set of SLN-positive patients with tumors ≤15 mm. Results: The data on 475 and 473 patients, respectively, were used for the validation. The areas under the receiver operating characteristic curves were similar to the originals for both predictive tools (.70 and .76). The lowest score of 1 identified 5 of 7 patients with disease limited to the SLNs and 161 of 165 as having less than 4 involved lymph nodes. Conclusions: A subset of patients with SLN-only involvement and less than 4 metastatic lymph nodes can probably be identified by means of the Louisville clinical prediction rules, but prediction of the lack of non-SLN metastasis seems less reliable.
AB - Background: Two recently developed clinical prediction rules aim to anticipate the lack of nonsentinel lymph node metastases and the involvement of less than 4 lymph nodes in breast cancer patients with positive sentinel lymph nodes (SLNs). Methods: The University of Louisville Breast SLN Study clinical prediction rules were validated on an independent set of SLN-positive patients with tumors ≤15 mm. Results: The data on 475 and 473 patients, respectively, were used for the validation. The areas under the receiver operating characteristic curves were similar to the originals for both predictive tools (.70 and .76). The lowest score of 1 identified 5 of 7 patients with disease limited to the SLNs and 161 of 165 as having less than 4 involved lymph nodes. Conclusions: A subset of patients with SLN-only involvement and less than 4 metastatic lymph nodes can probably be identified by means of the Louisville clinical prediction rules, but prediction of the lack of non-SLN metastasis seems less reliable.
KW - Breast cancer
KW - Clinical prediction rules
KW - Nonsentinel lymph nodes
KW - Postmastectomy radiation therapy
KW - Sentinel lymph nodes
KW - T1 tumors
UR - http://www.scopus.com/inward/record.url?scp=34547778421&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547778421&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2007.02.014
DO - 10.1016/j.amjsurg.2007.02.014
M3 - Article
VL - 194
SP - 288
EP - 293
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 3
ER -