Validation of EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient indexes (ESSPRI)

Raphaèle Seror, Elke Theander, Johan G. Brun, Manel Ramos-Casals, Valeria Valim, Thomas Dörner, Hendrika Bootsma, Athanasios Tzioufas, Roser Solans-Laqué, Thomas Mandl, Jacques Eric Gottenberg, Eric Hachulla, Kathy L. Sivils, Wan Fai Ng, Anne Laure Fauchais, Stefano Bombardieri, Guido Valesini, Elena Bartoloni, Alain Saraux, Matija TomsicTakayuki Sumida, Sumusu Nishiyama, Roberto Caporali, Aike A. Kruize, Cristina Vollenweider, Philippe Ravaud, Claudio Vitali, Xavier Mariette, Simon J. Bowman, Roberto Gerli, Salvatore De Vita, Valerie Devauchelle, Carlomaurizio Montecucco, Sonja Praprotnik, Hal Scofield

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To validate the two recently developed disease activity indexes for assessment of primary Sjögren's syndrome (SS): the European League Against Rheumatism (EULAR) SS Patient Reported Index (ESSPRI) and the EULAR SS Disease Activity Index (ESSDAI). Methods: A prospective international 6-month duration validation study was conducted in 15 countries. At each visit, physicians completed ESSDAI, SS disease activity index (SSDAI), Sjögren's Systemic Clinical Activity Index (SCAI) and physician global assessment (PhGA); and patients completed ESSPRI, Sicca Symptoms Inventory (SSI), Profile of Fatigue and Discomfort (PROFAD) and patient global assessment (PGA). Psychometric properties (construct validity, responsiveness and reliability) were evaluated and compared between scores. Results: Of the 395 patients included, 145 (37%) and 251 (64%) had currently active or current or past systemic manifestations, respectively. EULAR scores had higher correlation with the gold standard than other scores (ESSDAI with PhGA: r=0.59; ESSRPI with PGA: r=0.70). Correlations between patient and systemic scores were very low (ranging from 0.07 to 0.29). All systemic scores had similar large responsiveness in improved patients. Responsiveness of patient scores was low but was significantly higher for ESSPRI compared with SSI and PROFAD. Reliability was very good for all scores. Conclusions: ESSDAI and ESSPRI had good construct validity. All scores were reliable. Systemic scores had a large sensitivity to change in patients whose disease activity improves. Patient scores had a small sensitivity to change, however, significantly better for ESSPRI. Systemic and patient scores poorly correlated, suggesting that they are 2 complementary components that should be both evaluated, but separately.

Original languageEnglish
JournalAnnals of the Rheumatic Diseases
DOIs
Publication statusAccepted/In press - Jan 17 2014

ASJC Scopus subject areas

  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology
  • Rheumatology

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