Validation of heel stick microsampling to optimize micafungin doses in neonates and young infants

Cinzia Auriti, Bianca Maria Goffredo, Maria Paola Ronchetti, Fiammetta Piersigilli, Sara Cairoli, Iliana Bersani, Andrea Dotta, Manjunath P. Pai

Research output: Contribution to journalArticle

Abstract

Major gaps exist in our knowledge of antimicrobial pharmacokinetics in critically ill neonates and infants that require validated microsampling and bioanalysis methods to support therapeutic drug monitoring. We compared serially collected intravenous (i.v.) and heel stick capillary (HSC)-sampled plasma concentrations of micafungin (8 mg/kg) in eight infants born preterm with systemic candidiasis. The mean (standard deviation) micafungin area under the plasma concentration-time curve to infinity (AUCinf) was 316 (65.0) h mg/liter based on HSC concentrations that strongly correlated (R2 = 0.92) with i.v. values to support dose adjustment.

Original languageEnglish
Article numbere01199
JournalAntimicrobial Agents and Chemotherapy
Volume62
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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Keywords

  • Antifungal agents
  • Antimicrobial agents
  • Candidiasis
  • Echinocandin
  • Heel stick
  • Micafungin
  • Microsampling
  • Neonates
  • Pediatric
  • Pharmacodynamics
  • Pharmacokinetics
  • Systemic candidiasis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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