TY - JOUR
T1 - Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy
AU - Fajkovic, Harun
AU - Mathieu, Romain
AU - Lucca, Ilaria
AU - Hiess, Manuela
AU - Hübner, Nicolai
AU - Al Awamlh, Bashir Al Hussein
AU - Lee, Richard
AU - Briganti, Alberto
AU - Karakiewicz, Pierre
AU - Lotan, Yair
AU - Roupret, Morgan
AU - Rink, Michael
AU - Kluth, Luis
AU - Loidl, Wolfgang
AU - Seitz, Christian
AU - Klatte, Tobias
AU - Kramer, Gero
AU - Susani, Martin
AU - Shariat, Shahrokh F.
PY - 2015/9/14
Y1 - 2015/9/14
N2 - Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P
AB - Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P
KW - Biochemical recurrence
KW - Localized prostate cancer
KW - Lymphovascular invasion
KW - Radical prostatectomy
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U2 - 10.1016/j.urolonc.2015.10.013
DO - 10.1016/j.urolonc.2015.10.013
M3 - Article
AN - SCOPUS:84959881608
JO - Urologic Oncology
JF - Urologic Oncology
SN - 1078-1439
ER -