Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy

Harun Fajkovic, Romain Mathieu, Ilaria Lucca, Manuela Hiess, Nicolai Hübner, Bashir Al Hussein Al Awamlh, Richard Lee, Alberto Briganti, Pierre Karakiewicz, Yair Lotan, Morgan Roupret, Michael Rink, Luis Kluth, Wolfgang Loidl, Christian Seitz, Tobias Klatte, Gero Kramer, Martin Susani, Shahrokh F. Shariat

Research output: Contribution to journalArticle

Abstract

Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P

Original languageEnglish
JournalUrologic Oncology: Seminars and Original Investigations
DOIs
Publication statusAccepted/In press - Sep 14 2015

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Prostatectomy
Recurrence
Neoplasm Grading
Lymph Node Excision
Prostatic Neoplasms

Keywords

  • Biochemical recurrence
  • Localized prostate cancer
  • Lymphovascular invasion
  • Radical prostatectomy

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy. / Fajkovic, Harun; Mathieu, Romain; Lucca, Ilaria; Hiess, Manuela; Hübner, Nicolai; Al Awamlh, Bashir Al Hussein; Lee, Richard; Briganti, Alberto; Karakiewicz, Pierre; Lotan, Yair; Roupret, Morgan; Rink, Michael; Kluth, Luis; Loidl, Wolfgang; Seitz, Christian; Klatte, Tobias; Kramer, Gero; Susani, Martin; Shariat, Shahrokh F.

In: Urologic Oncology: Seminars and Original Investigations, 14.09.2015.

Research output: Contribution to journalArticle

Fajkovic, H, Mathieu, R, Lucca, I, Hiess, M, Hübner, N, Al Awamlh, BAH, Lee, R, Briganti, A, Karakiewicz, P, Lotan, Y, Roupret, M, Rink, M, Kluth, L, Loidl, W, Seitz, C, Klatte, T, Kramer, G, Susani, M & Shariat, SF 2015, 'Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy', Urologic Oncology: Seminars and Original Investigations. https://doi.org/10.1016/j.urolonc.2015.10.013
Fajkovic, Harun ; Mathieu, Romain ; Lucca, Ilaria ; Hiess, Manuela ; Hübner, Nicolai ; Al Awamlh, Bashir Al Hussein ; Lee, Richard ; Briganti, Alberto ; Karakiewicz, Pierre ; Lotan, Yair ; Roupret, Morgan ; Rink, Michael ; Kluth, Luis ; Loidl, Wolfgang ; Seitz, Christian ; Klatte, Tobias ; Kramer, Gero ; Susani, Martin ; Shariat, Shahrokh F. / Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy. In: Urologic Oncology: Seminars and Original Investigations. 2015.
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AU - Fajkovic, Harun

AU - Mathieu, Romain

AU - Lucca, Ilaria

AU - Hiess, Manuela

AU - Hübner, Nicolai

AU - Al Awamlh, Bashir Al Hussein

AU - Lee, Richard

AU - Briganti, Alberto

AU - Karakiewicz, Pierre

AU - Lotan, Yair

AU - Roupret, Morgan

AU - Rink, Michael

AU - Kluth, Luis

AU - Loidl, Wolfgang

AU - Seitz, Christian

AU - Klatte, Tobias

AU - Kramer, Gero

AU - Susani, Martin

AU - Shariat, Shahrokh F.

PY - 2015/9/14

Y1 - 2015/9/14

N2 - Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P

AB - Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P

KW - Biochemical recurrence

KW - Localized prostate cancer

KW - Lymphovascular invasion

KW - Radical prostatectomy

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