Abstract
Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P
| Original language | English |
|---|---|
| Journal | Urologic Oncology: Seminars and Original Investigations |
| DOIs | |
| Publication status | Accepted/In press - Sep 14 2015 |
Fingerprint
Keywords
- Biochemical recurrence
- Localized prostate cancer
- Lymphovascular invasion
- Radical prostatectomy
ASJC Scopus subject areas
- Oncology
- Urology
Cite this
Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy. / Fajkovic, Harun; Mathieu, Romain; Lucca, Ilaria; Hiess, Manuela; Hübner, Nicolai; Al Awamlh, Bashir Al Hussein; Lee, Richard; Briganti, Alberto; Karakiewicz, Pierre; Lotan, Yair; Roupret, Morgan; Rink, Michael; Kluth, Luis; Loidl, Wolfgang; Seitz, Christian; Klatte, Tobias; Kramer, Gero; Susani, Martin; Shariat, Shahrokh F.
In: Urologic Oncology: Seminars and Original Investigations, 14.09.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validation of lymphovascular invasion is an independent prognostic factor for biochemical recurrence after radical prostatectomy
AU - Fajkovic, Harun
AU - Mathieu, Romain
AU - Lucca, Ilaria
AU - Hiess, Manuela
AU - Hübner, Nicolai
AU - Al Awamlh, Bashir Al Hussein
AU - Lee, Richard
AU - Briganti, Alberto
AU - Karakiewicz, Pierre
AU - Lotan, Yair
AU - Roupret, Morgan
AU - Rink, Michael
AU - Kluth, Luis
AU - Loidl, Wolfgang
AU - Seitz, Christian
AU - Klatte, Tobias
AU - Kramer, Gero
AU - Susani, Martin
AU - Shariat, Shahrokh F.
PY - 2015/9/14
Y1 - 2015/9/14
N2 - Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P
AB - Objective: To validate the impact of lymphovascular invasion (LVI) on biochemical recurrence (BCR) in patients treated with radical prostatectomy (RP) in a large multiinstitutional cohort. Material and methods: Retrospective data from 6,678 patients treated with a RP and bilateral lymphadenectomy for prostate cancer (PC) from 8 centers were collected. The primary endpoint was BCR. Results: Overall, 767 patients (11.5%) had LVI. Patients with LVI had significantly higher Gleason scores (P = 0.01). After a median follow-up of 28 months (interquartile range: 21-44), patients with LVI had a 1.66 fold increased risk of BCR (P
KW - Biochemical recurrence
KW - Localized prostate cancer
KW - Lymphovascular invasion
KW - Radical prostatectomy
UR - http://www.scopus.com/inward/record.url?scp=84959881608&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959881608&partnerID=8YFLogxK
U2 - 10.1016/j.urolonc.2015.10.013
DO - 10.1016/j.urolonc.2015.10.013
M3 - Article
AN - SCOPUS:84959881608
JO - Urologic Oncology
JF - Urologic Oncology
SN - 1078-1439
ER -