Validation of the besta neurological institute rating scale for myasthenia gravis

Carlo Antozzi, Greta Brenna, Fulvio Baggi, Giorgia Camera, Lorenzo Maggi, Cristiana Rezzani, Cristina Montomoli, Renato Mantegazza

Research output: Contribution to journalArticlepeer-review


Introduction: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB-MG scale). Methods: A total of 174 patients were evaluated with the INCB-MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB-MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results: Generalized and bulbar INCB-MG subscales were unidimensional with excellent consistency; the INCB-MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB-MG generalized, bulbar, and respiratory subscales. Conclusions: The INCB-MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB-MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalMuscle and Nerve
Issue number1
Publication statusPublished - Jan 1 2016


  • Disability
  • Myasthenia Gravis
  • Outcome
  • Rating scale
  • Validation

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology


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