Validation of the besta neurological institute rating scale for myasthenia gravis

Carlo Antozzi; Greta Brenna; Fulvio Baggi; Giorgia Camera; Lorenzo Maggi; Cristiana Rezzani; Cristina Montomoli; Renato Mantegazza

doi:10.1002/mus.24911

Validation of the besta neurological institute rating scale for myasthenia gravis

Carlo Antozzi, Greta Brenna, Fulvio Baggi, Giorgia Camera, Lorenzo Maggi, Cristiana Rezzani, Cristina Montomoli, Renato Mantegazza

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB-MG scale). Methods: A total of 174 patients were evaluated with the INCB-MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB-MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results: Generalized and bulbar INCB-MG subscales were unidimensional with excellent consistency; the INCB-MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB-MG generalized, bulbar, and respiratory subscales. Conclusions: The INCB-MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB-MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials.

Original language	English
Pages (from-to)	32-37
Number of pages	6
Journal	Muscle and Nerve
Volume	53
Issue number	1
DOIs	https://doi.org/10.1002/mus.24911
Publication status	Published - Jan 1 2016

Keywords

Disability
Myasthenia Gravis
Outcome
Rating scale
Validation

ASJC Scopus subject areas

Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)
Physiology

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10.1002/mus.24911

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title = "Validation of the besta neurological institute rating scale for myasthenia gravis",

abstract = "Introduction: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB-MG scale). Methods: A total of 174 patients were evaluated with the INCB-MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB-MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results: Generalized and bulbar INCB-MG subscales were unidimensional with excellent consistency; the INCB-MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB-MG generalized, bulbar, and respiratory subscales. Conclusions: The INCB-MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB-MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials.",

keywords = "Disability, Myasthenia Gravis, Outcome, Rating scale, Validation",

author = "Carlo Antozzi and Greta Brenna and Fulvio Baggi and Giorgia Camera and Lorenzo Maggi and Cristiana Rezzani and Cristina Montomoli and Renato Mantegazza",

year = "2016",

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doi = "10.1002/mus.24911",

language = "English",

volume = "53",

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AU - Antozzi, Carlo

AU - Brenna, Greta

AU - Baggi, Fulvio

AU - Camera, Giorgia

AU - Maggi, Lorenzo

AU - Rezzani, Cristiana

AU - Montomoli, Cristina

AU - Mantegazza, Renato

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Introduction: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB-MG scale). Methods: A total of 174 patients were evaluated with the INCB-MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB-MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results: Generalized and bulbar INCB-MG subscales were unidimensional with excellent consistency; the INCB-MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB-MG generalized, bulbar, and respiratory subscales. Conclusions: The INCB-MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB-MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials.

AB - Introduction: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB-MG scale). Methods: A total of 174 patients were evaluated with the INCB-MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB-MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results: Generalized and bulbar INCB-MG subscales were unidimensional with excellent consistency; the INCB-MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB-MG generalized, bulbar, and respiratory subscales. Conclusions: The INCB-MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB-MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials.

KW - Disability

KW - Myasthenia Gravis

KW - Outcome

KW - Rating scale

KW - Validation

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Validation of the besta neurological institute rating scale for myasthenia gravis

Abstract

Keywords

ASJC Scopus subject areas

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