Validation of the classification criteria for cryoglobulinaemic vasculitis

Luca Quartuccio; Miriam Isola; Laura Corazza; Manuel Ramos-Casals; Soledad Retamozo; Gaafar M ohamed Ragab; Mostafa N aguib Zoheir; Manal A bdel Moneim El-Menyawi; Mohamed N abil Salem; Domenico Sansonno; Gianfranco Ferraccioli; Elisa Gremese; Athanasios Tzioufas; Michael Voulgarelis; Dimitris Vassilopoulos; Salvatore Scarpato; Nicolò Pipitone; Carlo Salvarani; Loic Guillevin; Benjamin Terrier; Patrice Cacoub; Davide Filippini; Francesco Saccardo; Armando Gabrielli; Paolo Fraticelli; Marco Sebastiani; Matija Tomsic; Antonio Tavoni; Cesare Mazzaro; Pietro Pioltelli; Norihiro Nishimoto; Patrizia Scaini; Anna L inda Zignego; Clodoveo Ferri; Giuseppe Monti; Maurizio Pietrogrande; Stefano Bombardieri; Massimo Galli; Salvatore De Vita

doi:10.1093/rheumatology/keu271

Validation of the classification criteria for cryoglobulinaemic vasculitis

Luca Quartuccio, Miriam Isola, Laura Corazza, Manuel Ramos-Casals, Soledad Retamozo, Gaafar M ohamed Ragab, Mostafa N aguib Zoheir, Manal A bdel Moneim El-Menyawi, Mohamed N abil Salem, Domenico Sansonno, Gianfranco Ferraccioli, Elisa Gremese, Athanasios Tzioufas, Michael Voulgarelis, Dimitris Vassilopoulos, Salvatore Scarpato, Nicolò Pipitone, Carlo Salvarani, Loic Guillevin, Benjamin TerrierPatrice Cacoub, Davide Filippini, Francesco Saccardo, Armando Gabrielli, Paolo Fraticelli, Marco Sebastiani, Matija Tomsic, Antonio Tavoni, Cesare Mazzaro, Pietro Pioltelli, Norihiro Nishimoto, Patrizia Scaini, Anna L inda Zignego, Clodoveo Ferri, Giuseppe Monti, Maurizio Pietrogrande, Stefano Bombardieri, Massimo Galli, Salvatore De Vita

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV).

METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard of clinical judgment (group B) and subjects without cryoglobulins but with clinical features that can be observed in the course of CV (group C), were studied. Positivity of serum cryoglobulins was necessary for CV classification. Sensitivity and specificity of the criteria were calculated by comparing group A vs group B. The group A vs group C comparison was done to demonstrate the possible diagnostic utility of the criteria.

RESULTS: The study included 268 patients in group A, 182 controls in group B and 193 controls in group C (small vessel vasculitis, 51.8%). The questionnaire (at least 2/3 positive answers) showed 89.0% sensitivity and 93.4% specificity; the clinical item (at least 3/4 clinical involvement) showed 75.7% sensitivity and 89.0% specificity and the laboratory item (at least 2/3 laboratory data) showed 80.2% sensitivity and 62.4% specificity. The sensitivity and specificity of the classification criteria (at least 2/3 positive items) were 89.9% and 93.5%, respectively. The comparison of group A with group C demonstrated the clinical utility of the criteria in differentiating CV from CV mimickers.

CONCLUSION: Classification criteria for CV were validated in a second, large, international study confirming good sensitivity and specificity in a complex systemic disease.

Original language	English
Pages (from-to)	2209-2213
Number of pages	5
Journal	Rheumatology
Volume	53
Issue number	12
DOIs	https://doi.org/10.1093/rheumatology/keu271
Publication status	Published - Dec 1 2014

Keywords

classification
cryoglobulinaemia
hepatitis C
vasculitis

ASJC Scopus subject areas

Medicine(all)

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Quartuccio, L., Isola, M., Corazza, L., Ramos-Casals, M., Retamozo, S., Ragab, G. M. O., Zoheir, M. N. A., El-Menyawi, M. A. B. M., Salem, M. N. A., Sansonno, D., Ferraccioli, G., Gremese, E., Tzioufas, A., Voulgarelis, M., Vassilopoulos, D., Scarpato, S., Pipitone, N., Salvarani, C., Guillevin, L., ... De Vita, S. (2014). Validation of the classification criteria for cryoglobulinaemic vasculitis. Rheumatology, 53(12), 2209-2213. https://doi.org/10.1093/rheumatology/keu271

Validation of the classification criteria for cryoglobulinaemic vasculitis. / Quartuccio, Luca; Isola, Miriam; Corazza, Laura; Ramos-Casals, Manuel; Retamozo, Soledad; Ragab, Gaafar M ohamed; Zoheir, Mostafa N aguib; El-Menyawi, Manal A bdel Moneim; Salem, Mohamed N abil; Sansonno, Domenico; Ferraccioli, Gianfranco; Gremese, Elisa; Tzioufas, Athanasios; Voulgarelis, Michael; Vassilopoulos, Dimitris; Scarpato, Salvatore; Pipitone, Nicolò; Salvarani, Carlo; Guillevin, Loic; Terrier, Benjamin; Cacoub, Patrice; Filippini, Davide; Saccardo, Francesco; Gabrielli, Armando; Fraticelli, Paolo; Sebastiani, Marco; Tomsic, Matija; Tavoni, Antonio; Mazzaro, Cesare; Pioltelli, Pietro; Nishimoto, Norihiro; Scaini, Patrizia; Zignego, Anna L inda; Ferri, Clodoveo; Monti, Giuseppe; Pietrogrande, Maurizio; Bombardieri, Stefano; Galli, Massimo; De Vita, Salvatore.

In: Rheumatology, Vol. 53, No. 12, 01.12.2014, p. 2209-2213.

Research output: Contribution to journal › Article › peer-review

Quartuccio, L, Isola, M, Corazza, L, Ramos-Casals, M, Retamozo, S, Ragab, GMO, Zoheir, MNA, El-Menyawi, MABM, Salem, MNA, Sansonno, D, Ferraccioli, G, Gremese, E, Tzioufas, A, Voulgarelis, M, Vassilopoulos, D, Scarpato, S, Pipitone, N, Salvarani, C, Guillevin, L, Terrier, B, Cacoub, P, Filippini, D, Saccardo, F, Gabrielli, A, Fraticelli, P, Sebastiani, M, Tomsic, M, Tavoni, A, Mazzaro, C, Pioltelli, P, Nishimoto, N, Scaini, P, Zignego, ALI, Ferri, C, Monti, G, Pietrogrande, M, Bombardieri, S, Galli, M & De Vita, S 2014, 'Validation of the classification criteria for cryoglobulinaemic vasculitis', Rheumatology, vol. 53, no. 12, pp. 2209-2213. https://doi.org/10.1093/rheumatology/keu271

Quartuccio, Luca ; Isola, Miriam ; Corazza, Laura ; Ramos-Casals, Manuel ; Retamozo, Soledad ; Ragab, Gaafar M ohamed ; Zoheir, Mostafa N aguib ; El-Menyawi, Manal A bdel Moneim ; Salem, Mohamed N abil ; Sansonno, Domenico ; Ferraccioli, Gianfranco ; Gremese, Elisa ; Tzioufas, Athanasios ; Voulgarelis, Michael ; Vassilopoulos, Dimitris ; Scarpato, Salvatore ; Pipitone, Nicolò ; Salvarani, Carlo ; Guillevin, Loic ; Terrier, Benjamin ; Cacoub, Patrice ; Filippini, Davide ; Saccardo, Francesco ; Gabrielli, Armando ; Fraticelli, Paolo ; Sebastiani, Marco ; Tomsic, Matija ; Tavoni, Antonio ; Mazzaro, Cesare ; Pioltelli, Pietro ; Nishimoto, Norihiro ; Scaini, Patrizia ; Zignego, Anna L inda ; Ferri, Clodoveo ; Monti, Giuseppe ; Pietrogrande, Maurizio ; Bombardieri, Stefano ; Galli, Massimo ; De Vita, Salvatore. / Validation of the classification criteria for cryoglobulinaemic vasculitis. In: Rheumatology. 2014 ; Vol. 53, No. 12. pp. 2209-2213.

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abstract = "OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV).METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard of clinical judgment (group B) and subjects without cryoglobulins but with clinical features that can be observed in the course of CV (group C), were studied. Positivity of serum cryoglobulins was necessary for CV classification. Sensitivity and specificity of the criteria were calculated by comparing group A vs group B. The group A vs group C comparison was done to demonstrate the possible diagnostic utility of the criteria.RESULTS: The study included 268 patients in group A, 182 controls in group B and 193 controls in group C (small vessel vasculitis, 51.8%). The questionnaire (at least 2/3 positive answers) showed 89.0% sensitivity and 93.4% specificity; the clinical item (at least 3/4 clinical involvement) showed 75.7% sensitivity and 89.0% specificity and the laboratory item (at least 2/3 laboratory data) showed 80.2% sensitivity and 62.4% specificity. The sensitivity and specificity of the classification criteria (at least 2/3 positive items) were 89.9% and 93.5%, respectively. The comparison of group A with group C demonstrated the clinical utility of the criteria in differentiating CV from CV mimickers.CONCLUSION: Classification criteria for CV were validated in a second, large, international study confirming good sensitivity and specificity in a complex systemic disease.",

keywords = "classification, cryoglobulinaemia, hepatitis C, vasculitis",

author = "Luca Quartuccio and Miriam Isola and Laura Corazza and Manuel Ramos-Casals and Soledad Retamozo and Ragab, {Gaafar M ohamed} and Zoheir, {Mostafa N aguib} and El-Menyawi, {Manal A bdel Moneim} and Salem, {Mohamed N abil} and Domenico Sansonno and Gianfranco Ferraccioli and Elisa Gremese and Athanasios Tzioufas and Michael Voulgarelis and Dimitris Vassilopoulos and Salvatore Scarpato and Nicol{\`o} Pipitone and Carlo Salvarani and Loic Guillevin and Benjamin Terrier and Patrice Cacoub and Davide Filippini and Francesco Saccardo and Armando Gabrielli and Paolo Fraticelli and Marco Sebastiani and Matija Tomsic and Antonio Tavoni and Cesare Mazzaro and Pietro Pioltelli and Norihiro Nishimoto and Patrizia Scaini and Zignego, {Anna L inda} and Clodoveo Ferri and Giuseppe Monti and Maurizio Pietrogrande and Stefano Bombardieri and Massimo Galli and {De Vita}, Salvatore",

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T1 - Validation of the classification criteria for cryoglobulinaemic vasculitis

AU - Quartuccio, Luca

AU - Isola, Miriam

AU - Corazza, Laura

AU - Ramos-Casals, Manuel

AU - Retamozo, Soledad

AU - Ragab, Gaafar M ohamed

AU - Zoheir, Mostafa N aguib

AU - El-Menyawi, Manal A bdel Moneim

AU - Salem, Mohamed N abil

AU - Sansonno, Domenico

AU - Ferraccioli, Gianfranco

AU - Gremese, Elisa

AU - Tzioufas, Athanasios

AU - Voulgarelis, Michael

AU - Vassilopoulos, Dimitris

AU - Scarpato, Salvatore

AU - Pipitone, Nicolò

AU - Salvarani, Carlo

AU - Guillevin, Loic

AU - Terrier, Benjamin

AU - Cacoub, Patrice

AU - Filippini, Davide

AU - Saccardo, Francesco

AU - Gabrielli, Armando

AU - Fraticelli, Paolo

AU - Sebastiani, Marco

AU - Tomsic, Matija

AU - Tavoni, Antonio

AU - Mazzaro, Cesare

AU - Pioltelli, Pietro

AU - Nishimoto, Norihiro

AU - Scaini, Patrizia

AU - Zignego, Anna L inda

AU - Ferri, Clodoveo

AU - Monti, Giuseppe

AU - Pietrogrande, Maurizio

AU - Bombardieri, Stefano

AU - Galli, Massimo

AU - De Vita, Salvatore

PY - 2014/12/1

Y1 - 2014/12/1

N2 - OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV).METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard of clinical judgment (group B) and subjects without cryoglobulins but with clinical features that can be observed in the course of CV (group C), were studied. Positivity of serum cryoglobulins was necessary for CV classification. Sensitivity and specificity of the criteria were calculated by comparing group A vs group B. The group A vs group C comparison was done to demonstrate the possible diagnostic utility of the criteria.RESULTS: The study included 268 patients in group A, 182 controls in group B and 193 controls in group C (small vessel vasculitis, 51.8%). The questionnaire (at least 2/3 positive answers) showed 89.0% sensitivity and 93.4% specificity; the clinical item (at least 3/4 clinical involvement) showed 75.7% sensitivity and 89.0% specificity and the laboratory item (at least 2/3 laboratory data) showed 80.2% sensitivity and 62.4% specificity. The sensitivity and specificity of the classification criteria (at least 2/3 positive items) were 89.9% and 93.5%, respectively. The comparison of group A with group C demonstrated the clinical utility of the criteria in differentiating CV from CV mimickers.CONCLUSION: Classification criteria for CV were validated in a second, large, international study confirming good sensitivity and specificity in a complex systemic disease.

AB - OBJECTIVE: The aim of this study was to validate the classification criteria for cryoglobulinaemic vasculitis (CV).METHODS: Twenty-three centres were involved. New patients with CV (group A) and controls, i.e. subjects with serum cryoglobulins but lacking CV based on the gold standard of clinical judgment (group B) and subjects without cryoglobulins but with clinical features that can be observed in the course of CV (group C), were studied. Positivity of serum cryoglobulins was necessary for CV classification. Sensitivity and specificity of the criteria were calculated by comparing group A vs group B. The group A vs group C comparison was done to demonstrate the possible diagnostic utility of the criteria.RESULTS: The study included 268 patients in group A, 182 controls in group B and 193 controls in group C (small vessel vasculitis, 51.8%). The questionnaire (at least 2/3 positive answers) showed 89.0% sensitivity and 93.4% specificity; the clinical item (at least 3/4 clinical involvement) showed 75.7% sensitivity and 89.0% specificity and the laboratory item (at least 2/3 laboratory data) showed 80.2% sensitivity and 62.4% specificity. The sensitivity and specificity of the classification criteria (at least 2/3 positive items) were 89.9% and 93.5%, respectively. The comparison of group A with group C demonstrated the clinical utility of the criteria in differentiating CV from CV mimickers.CONCLUSION: Classification criteria for CV were validated in a second, large, international study confirming good sensitivity and specificity in a complex systemic disease.

KW - classification

KW - cryoglobulinaemia

KW - hepatitis C

KW - vasculitis

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