Validation of the inflammatory bowel disease disability index in a population-based cohort

Corinne Gower-Rousseau, Hélène Sarter, Guillaume Savoye, Noémie Tavernier, Mathurin Fumery, William J. Sandborn, Brian G. Feagan, Alain Duhamel, Nathalie Guillon-Dellac, Jean Frédéric Colombel, Laurent Peyrin-Biroulet, Walter Reinisch, Herbert Tilg, Michael Kamm, Geert D'Haens, Edouard Louis, Geert Van Assche, Brian Feagan, E. Jan Irvine, Pierre MichettiToshifumi Hibi, Jürgen Schölmerich, Stefan Schreiber, Pia Munkholm, Julian Panes, Cieza Alarcos, Jacques Cosnes, Marc Lémann, Maïté Lewin, Jean Yves Mary, Benjamin Pariente, Laurent peyrin-Biroulet, Simon Travis, Yehuda Chowers, Silvio Danese, Maurizio Vecchi, Daan W. Hommes, Tom Oresland, Joel Fletcher, Edward V. Loftus, J. Wlliam Sandborn, Bruce E. Sands

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Abstract

Background IBDs are chronic destructive disorders that negatively affect the functional status of patients. Recently, the Inflammatory Bowel Disease Disability Index (IBD-DI) was developed according to standard WHO processes. The aims of the current study were to validate the IBD-DI in an independent patient cohort, to develop an index-specific scoring system and to describe the disability status of a well-defined population-based cohort of French patients with IBD. Methods From February 2012 to March 2014, the IBD-DI questionnaire was administered to a random sample of adult patients with an established diagnosis of IBD issued from a French population-based registry. The IBD-DI consists of 28 items that evaluate the four domains of body functions, activity participation, body structures and environmental factors. Validation included item reduction and data structure, construct validity, internal consistency, interobserver and intraobserver reliability evaluations. Results 150 patients with Crohn's disease (CD) and 50 patients with UC completed the IBD-DI validation phase. The intraclass correlation coefficient for interobserver reliability was 0.91 and 0.54 for intraobserver reliability. Cronbach's α of internal consistency was 0.86. IBD-DI scores varied from 0 to 100 with a mean of 35.3 (Q1=19.6; Q3=51.8). IBD-DI scores were highly correlated with Inflammatory Bowel Disease Questionnaire (-0.82; p

Original languageEnglish
JournalGut
DOIs
Publication statusAccepted/In press - Dec 8 2015

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ASJC Scopus subject areas

  • Gastroenterology

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Gower-Rousseau, C., Sarter, H., Savoye, G., Tavernier, N., Fumery, M., Sandborn, W. J., Feagan, B. G., Duhamel, A., Guillon-Dellac, N., Colombel, J. F., Peyrin-Biroulet, L., Reinisch, W., Tilg, H., Kamm, M., D'Haens, G., Louis, E., Assche, G. V., Feagan, B., Irvine, E. J., ... Sands, B. E. (Accepted/In press). Validation of the inflammatory bowel disease disability index in a population-based cohort. Gut. https://doi.org/10.1136/gutjnl-2015-310151