Validation of the IOF quality of life questionnaire for patients with wrist fracture

P. Lips, K. Jameson, M. L. Bianchi, S. Goemaere, S. Boonen, J. Reeve, J. Stepan, O. Johnell, N. M. Van Schoor, E. Dennison, J. A. Kanis, C. Cooper

Research output: Contribution to journalArticlepeer-review


Introduction: Wrist fracture causes pain and decreased physical, social and emotional function. The International Osteoporosis Foundation has developed a specific questionnaire to assess quality of life in patients with wrist fracture. This questionnaire, including 12 questions, was validated in a multicentre study and compared with an osteoporosis-specific questionnaire (Qualeffo-41) and a generic questionnaire (EQ-5D). Methods: The study included 105 patients with a recent wrist fracture and 74 sex- and age-matched control subjects. The questionnaire was administered as soon as possible after the fracture, at 6 weeks, 3 months, 6 months and 1 year after the fracture. Test-retest reproducibility, internal consistency and sensitivity to change were assessed. Results and discussion: The results showed adequate repeatability and internal consistency of the International Osteoporosis Foundation (IOF) wrist fracture questionnaire. The discriminatory capacity between patients and control subjects was very high, with significant odds ratios for each question and domain. The IOF-wrist fracture questionnaire domain scores showed significant improvement after 3 and 6 months and some improvement from 6 months up to 1 year. The sensitivity to change was much higher for the IOF-wrist fracture total score than for Qualeffo-41 and EQ-5D. Conclusion: In conclusion, the IOF-wrist fracture questionnaire appears to be a reliable and responsive quality of life questionnaire.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalOsteoporosis International
Issue number1
Publication statusPublished - Jan 2010


  • Distal forearm fracture
  • EQ-5D
  • Qualeffo-41
  • Quality of life
  • Utility
  • Wrist fracture

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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