Validation of the Italian version of the PSP Quality of Life questionnaire

Marina Picillo, Sofia Cuoco, Marianna Amboni, Francesco Paolo Bonifacio, Fabio Bruschi, Immacolata Carotenuto, Rosa De Micco, Anna De Rosa, Eleonora Del Prete, Francesca Di Biasio, Francesca Elifani, Roberto Erro, Margherita Fabbri, Marika Falla, Giulia Franco, Daniela Frosini, Sebastiano Galantucci, Giulia Lazzeri, Luca Magistrelli, Maria Chiara Malaguti & 23 others Anna Vera Milner, Brigida Minafra, Enrica Olivola, Andrea Pilotto, Cristina Rascunà, Maria Cristina Rizzetti, Tommaso Schirinzi, Barbara Borroni, Roberto Ceravolo, Alessio Di Fonzo, Roberta Marchese, Nicola B. Mercuri, Nicola Modugno, Alessandra Nicoletti, Alessandro Padovani, Gabriella Santangelo, Alessandro Stefani, Alessandro Tessitore, Maria Antonietta Volontè, Roberta Zangaglia, Mario Zappia, Maurizio Zibetti, Paolo Barone

Research output: Contribution to journalArticle

Abstract

Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.

Original languageEnglish
JournalNeurological Sciences
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Progressive Supranuclear Palsy
Quality of Life
Neurodegenerative Diseases
Surveys and Questionnaires
Geographic Locations
Movement Disorders
Eye Movements
Italy
Health Status

Keywords

  • Clinical trials
  • Parkinsonism
  • Progressive supranuclear palsy
  • Quality of life

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Picillo, M., Cuoco, S., Amboni, M., Bonifacio, F. P., Bruschi, F., Carotenuto, I., ... Barone, P. (2019). Validation of the Italian version of the PSP Quality of Life questionnaire. Neurological Sciences. https://doi.org/10.1007/s10072-019-04010-2

Validation of the Italian version of the PSP Quality of Life questionnaire. / Picillo, Marina; Cuoco, Sofia; Amboni, Marianna; Bonifacio, Francesco Paolo; Bruschi, Fabio; Carotenuto, Immacolata; De Micco, Rosa; De Rosa, Anna; Del Prete, Eleonora; Di Biasio, Francesca; Elifani, Francesca; Erro, Roberto; Fabbri, Margherita; Falla, Marika; Franco, Giulia; Frosini, Daniela; Galantucci, Sebastiano; Lazzeri, Giulia; Magistrelli, Luca; Malaguti, Maria Chiara; Milner, Anna Vera; Minafra, Brigida; Olivola, Enrica; Pilotto, Andrea; Rascunà, Cristina; Rizzetti, Maria Cristina; Schirinzi, Tommaso; Borroni, Barbara; Ceravolo, Roberto; Di Fonzo, Alessio; Marchese, Roberta; Mercuri, Nicola B.; Modugno, Nicola; Nicoletti, Alessandra; Padovani, Alessandro; Santangelo, Gabriella; Stefani, Alessandro; Tessitore, Alessandro; Volontè, Maria Antonietta; Zangaglia, Roberta; Zappia, Mario; Zibetti, Maurizio; Barone, Paolo.

In: Neurological Sciences, 01.01.2019.

Research output: Contribution to journalArticle

Picillo, M, Cuoco, S, Amboni, M, Bonifacio, FP, Bruschi, F, Carotenuto, I, De Micco, R, De Rosa, A, Del Prete, E, Di Biasio, F, Elifani, F, Erro, R, Fabbri, M, Falla, M, Franco, G, Frosini, D, Galantucci, S, Lazzeri, G, Magistrelli, L, Malaguti, MC, Milner, AV, Minafra, B, Olivola, E, Pilotto, A, Rascunà, C, Rizzetti, MC, Schirinzi, T, Borroni, B, Ceravolo, R, Di Fonzo, A, Marchese, R, Mercuri, NB, Modugno, N, Nicoletti, A, Padovani, A, Santangelo, G, Stefani, A, Tessitore, A, Volontè, MA, Zangaglia, R, Zappia, M, Zibetti, M & Barone, P 2019, 'Validation of the Italian version of the PSP Quality of Life questionnaire', Neurological Sciences. https://doi.org/10.1007/s10072-019-04010-2
Picillo, Marina ; Cuoco, Sofia ; Amboni, Marianna ; Bonifacio, Francesco Paolo ; Bruschi, Fabio ; Carotenuto, Immacolata ; De Micco, Rosa ; De Rosa, Anna ; Del Prete, Eleonora ; Di Biasio, Francesca ; Elifani, Francesca ; Erro, Roberto ; Fabbri, Margherita ; Falla, Marika ; Franco, Giulia ; Frosini, Daniela ; Galantucci, Sebastiano ; Lazzeri, Giulia ; Magistrelli, Luca ; Malaguti, Maria Chiara ; Milner, Anna Vera ; Minafra, Brigida ; Olivola, Enrica ; Pilotto, Andrea ; Rascunà, Cristina ; Rizzetti, Maria Cristina ; Schirinzi, Tommaso ; Borroni, Barbara ; Ceravolo, Roberto ; Di Fonzo, Alessio ; Marchese, Roberta ; Mercuri, Nicola B. ; Modugno, Nicola ; Nicoletti, Alessandra ; Padovani, Alessandro ; Santangelo, Gabriella ; Stefani, Alessandro ; Tessitore, Alessandro ; Volontè, Maria Antonietta ; Zangaglia, Roberta ; Zappia, Mario ; Zibetti, Maurizio ; Barone, Paolo. / Validation of the Italian version of the PSP Quality of Life questionnaire. In: Neurological Sciences. 2019.
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title = "Validation of the Italian version of the PSP Quality of Life questionnaire",
abstract = "Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.",
keywords = "Clinical trials, Parkinsonism, Progressive supranuclear palsy, Quality of life",
author = "Marina Picillo and Sofia Cuoco and Marianna Amboni and Bonifacio, {Francesco Paolo} and Fabio Bruschi and Immacolata Carotenuto and {De Micco}, Rosa and {De Rosa}, Anna and {Del Prete}, Eleonora and {Di Biasio}, Francesca and Francesca Elifani and Roberto Erro and Margherita Fabbri and Marika Falla and Giulia Franco and Daniela Frosini and Sebastiano Galantucci and Giulia Lazzeri and Luca Magistrelli and Malaguti, {Maria Chiara} and Milner, {Anna Vera} and Brigida Minafra and Enrica Olivola and Andrea Pilotto and Cristina Rascun{\`a} and Rizzetti, {Maria Cristina} and Tommaso Schirinzi and Barbara Borroni and Roberto Ceravolo and {Di Fonzo}, Alessio and Roberta Marchese and Mercuri, {Nicola B.} and Nicola Modugno and Alessandra Nicoletti and Alessandro Padovani and Gabriella Santangelo and Alessandro Stefani and Alessandro Tessitore and Volont{\`e}, {Maria Antonietta} and Roberta Zangaglia and Mario Zappia and Maurizio Zibetti and Paolo Barone",
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AU - Picillo, Marina

AU - Cuoco, Sofia

AU - Amboni, Marianna

AU - Bonifacio, Francesco Paolo

AU - Bruschi, Fabio

AU - Carotenuto, Immacolata

AU - De Micco, Rosa

AU - De Rosa, Anna

AU - Del Prete, Eleonora

AU - Di Biasio, Francesca

AU - Elifani, Francesca

AU - Erro, Roberto

AU - Fabbri, Margherita

AU - Falla, Marika

AU - Franco, Giulia

AU - Frosini, Daniela

AU - Galantucci, Sebastiano

AU - Lazzeri, Giulia

AU - Magistrelli, Luca

AU - Malaguti, Maria Chiara

AU - Milner, Anna Vera

AU - Minafra, Brigida

AU - Olivola, Enrica

AU - Pilotto, Andrea

AU - Rascunà, Cristina

AU - Rizzetti, Maria Cristina

AU - Schirinzi, Tommaso

AU - Borroni, Barbara

AU - Ceravolo, Roberto

AU - Di Fonzo, Alessio

AU - Marchese, Roberta

AU - Mercuri, Nicola B.

AU - Modugno, Nicola

AU - Nicoletti, Alessandra

AU - Padovani, Alessandro

AU - Santangelo, Gabriella

AU - Stefani, Alessandro

AU - Tessitore, Alessandro

AU - Volontè, Maria Antonietta

AU - Zangaglia, Roberta

AU - Zappia, Mario

AU - Zibetti, Maurizio

AU - Barone, Paolo

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.

AB - Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP.

KW - Clinical trials

KW - Parkinsonism

KW - Progressive supranuclear palsy

KW - Quality of life

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DO - 10.1007/s10072-019-04010-2

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