Validation of the Italian version of the PSP Quality of Life questionnaire: Neurological Sciences

M Picillo, S Cuoco, M Amboni, FP Bonifacio, F Bruschi, I Carotenuto, R De Micco, A De Rosa, E Del Prete, F Di Biasio, F Elifani, R Erro, M Fabbri, M Falla, G Franco, D Frosini, S Galantucci, G Lazzeri, L Magistrelli, MC MalagutiAV Milner, B Minafra, E Olivola, A Pilotto, C Rascunà, MC Rizzetti, T Schirinzi, B Borroni, R Ceravolo, A Di Fonzo, R Marchese, NB Mercuri, N Modugno, A Nicoletti, A Padovani, G Santangelo, A Stefani, A Tessitore, MA Volontè, R Zangaglia, M Zappia, M Zibetti, P Barone

Research output: Contribution to journalArticlepeer-review


Background: Progressive supranuclear palsy (PSP) is a rare rapidly progressive, neurodegenerative disease characterized by falls and ocular movement disturbances. The use of health-related quality of life (HR-QoL) measures allows assessing changes in health status induced by therapeutic interventions or disease progress in neurodegenerative diseases. The PSP-QoL is a 45-item, self-administered questionnaire designed to evaluate HR-QoL in PSP. Methods and Results: Here, the PSP-QoL was translated into Italian and validated in 190 PSP (96 women and 94 men; mean age ± standard deviation, 72 ± 6.5; mean disease duration, 4.2 ± 2.3) patients diagnosed according to the Movement Disorder Society criteria and recruited in 16 third level movement disorders centers participating in the Neurecanet project. The mean PSP-QoL total score was 77.8 ± 37 (physical subscore, 46.5 ± 18.7; mental subscore, 33.6 ± 19.2). The internal consistency was high (Cronbach’s alpha = 0.954); corrected item-total correlation was > 0.40 for the majority of items. The significant and moderate correlation of the PSP-QoL with other HR-QoL measures as well as with motor and disability assessments indicated adequate convergent validity of the scale. Gender and geographic location presented a significant impact on the PSP-QoL in our sample with women and patients from the South of Italy scoring higher than their counterparts. Conclusion: In conclusion, the Italian version of the PSP-QoL is an easy, reliable and valid tool for assessment of HR-QoL in PSP. © 2019, Fondazione Società Italiana di Neurologia.
Original languageEnglish
Pages (from-to)2587-2594
Number of pages8
JournalNeurol. Sci.
Issue number12
Publication statusPublished - 2019


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