Abstract
Occupational exposure to antineoplastic cytostatic drugs has been recognized as a potential health hazard since the seventies. Safety guidelines and recommendations have been published in several countries in order to improve operating procedures and keep exposure levels as low as possible. Nevertheless, contamination still occurs. With a view to preventing exposure, standardized authorized methods and a mandatory monitoring system appear to be an essential prerequisite. First of all, reliable analytical methods are necessary, and a wide number of drugs should be monitored, on the basis of the continual change in the treatment protocols. In fact, most of the methods available in the literature were not properly validated, and a lack of details concerning quality assurance is clearly observed. When assessing analytical methods applied for routine testing, validation studies are of utmost importance. Not only performance parameters, such as sensitivity, specificity, LOD and LLQ, should therefore be determined, but also the uncertainty of measurement, which gives a measure of the confidence that can be placed on the results.
| Original language | English |
|---|---|
| Pages (from-to) | 256-262 |
| Number of pages | 7 |
| Journal | Toxicology Letters |
| Volume | 162 |
| Issue number | 2-3 SPEC. ISS. |
| DOIs | |
| Publication status | Published - Apr 10 2006 |
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Keywords
- Antineoplastic drugs
- Biological monitoring
- Quality assurance
- Uncertainty of measurement
ASJC Scopus subject areas
- Toxicology
Cite this
Validation protocol and analytical quality in biological monitoring of occupational exposure to antineoplastic drugs. / Turci, Roberta; Sottani, Cristina; Schierl, Rudolf; Minoia, Claudio.
In: Toxicology Letters, Vol. 162, No. 2-3 SPEC. ISS., 10.04.2006, p. 256-262.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Validation protocol and analytical quality in biological monitoring of occupational exposure to antineoplastic drugs
AU - Turci, Roberta
AU - Sottani, Cristina
AU - Schierl, Rudolf
AU - Minoia, Claudio
PY - 2006/4/10
Y1 - 2006/4/10
N2 - Occupational exposure to antineoplastic cytostatic drugs has been recognized as a potential health hazard since the seventies. Safety guidelines and recommendations have been published in several countries in order to improve operating procedures and keep exposure levels as low as possible. Nevertheless, contamination still occurs. With a view to preventing exposure, standardized authorized methods and a mandatory monitoring system appear to be an essential prerequisite. First of all, reliable analytical methods are necessary, and a wide number of drugs should be monitored, on the basis of the continual change in the treatment protocols. In fact, most of the methods available in the literature were not properly validated, and a lack of details concerning quality assurance is clearly observed. When assessing analytical methods applied for routine testing, validation studies are of utmost importance. Not only performance parameters, such as sensitivity, specificity, LOD and LLQ, should therefore be determined, but also the uncertainty of measurement, which gives a measure of the confidence that can be placed on the results.
AB - Occupational exposure to antineoplastic cytostatic drugs has been recognized as a potential health hazard since the seventies. Safety guidelines and recommendations have been published in several countries in order to improve operating procedures and keep exposure levels as low as possible. Nevertheless, contamination still occurs. With a view to preventing exposure, standardized authorized methods and a mandatory monitoring system appear to be an essential prerequisite. First of all, reliable analytical methods are necessary, and a wide number of drugs should be monitored, on the basis of the continual change in the treatment protocols. In fact, most of the methods available in the literature were not properly validated, and a lack of details concerning quality assurance is clearly observed. When assessing analytical methods applied for routine testing, validation studies are of utmost importance. Not only performance parameters, such as sensitivity, specificity, LOD and LLQ, should therefore be determined, but also the uncertainty of measurement, which gives a measure of the confidence that can be placed on the results.
KW - Antineoplastic drugs
KW - Biological monitoring
KW - Quality assurance
KW - Uncertainty of measurement
UR - http://www.scopus.com/inward/record.url?scp=32644437821&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=32644437821&partnerID=8YFLogxK
U2 - 10.1016/j.toxlet.2005.09.022
DO - 10.1016/j.toxlet.2005.09.022
M3 - Article
C2 - 16246507
AN - SCOPUS:32644437821
VL - 162
SP - 256
EP - 262
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 2-3 SPEC. ISS.
ER -