Validity and clinical utility of the aspartate aminotransferase-alanine aminotransferase ratio in assessing disease severity and prognosis in patients with hepatitis C virus-related chronic liver disease

Edoardo Giannini, Domenico Risso, Federica Botta, Bruno Chiarbonello, Alberto Fasoli, Federica Malfatti, Paola Romagnoli, Emanuela Testa, Paola Ceppa, Roberto Testa

Research output: Contribution to journalArticle

Abstract

Background: The aspartate aminotransferase-alanine aminotransferase ratio (AST/ALT ratio) has been used to noninvasively assess the severity of disease in patients with chronic liver disease (CLD). We previously demonstrated that progressive liver functional impairment is associated with an increase in the AST/ALT ratio. Objectives: To evaluate the reproducibility and transportability of the AST/ALT ratio in a large cohort of patients with different degrees of hepatitis C virus (HCV)-related CLD, to confirm the correlation between progressive impairment of liver function and increase in the AST/ALT ratio, to evaluate whether diagnostic accuracy of the ALT/AST ratio can be improved by using it with other biochemical variables, and to assess the 1-year prognostic capability of the AST/ALT ratio in patients with liver cirrhosis. Patients and Methods: We retrospectively evaluated 252 patients with HCV-related CLD. The AST/ALT ratio was correlated with the degree of liver fibrosis in patients with chronic hepatitis and with the Child-Pugh score in patients with cirrhosis. All patients had undergone monoethylglycinexylidide (MEGX) testing to evaluate liver function. We assessed the prognostic ability of the AST/ALT ratio in a subset of 63 cirrhotic patients who were followed up for at least 1 year. Results: The AST/ALT ratio was more frequently 1 or higher in cirrhotic patients (Ps=-0.621, P

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalArchives of Internal Medicine
Volume163
Issue number2
DOIs
Publication statusPublished - Jan 27 2003

ASJC Scopus subject areas

  • Internal Medicine

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