Valproate as a mainstay of therapy for pediatric epilepsy

Renzo Guerrini

Research output: Contribution to journalArticlepeer-review


This article reviews relevant pharmacologic and clinical information gathered for valproate since it was introduced into clinical practice 37 years ago and the application of this information for the treatment of childhood epilepsy. Valproate is available for oral and parenteral use. Oral forms are almost completely bioavailable but the rate of absorption varies between formulations. The Chrono® tablet formulation has not been adapted for children aged

Original languageEnglish
Pages (from-to)113-129
Number of pages17
JournalPediatric Drugs
Issue number2
Publication statusPublished - 2006

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology


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