Valproate induced hyperammonemic encephalopathy successfully treated with levocarnitine

Andrea Rigamonti, Giuseppe Lauria, Gianluca Grimod, Graziella Bianchi, Andrea Salmaggi

Research output: Contribution to journalArticlepeer-review


Valproate-induced hyperammonemic encephalopathy is an unusual but serious adverse effect that is usually characterized by the acute onset of impaired consciousness, focal neurological symptoms and increased seizure frequency. It has been reported to occur at therapeutic valproate levels. We report a patient who developed valproate-induced hyperammonemic encephalopathy after a short treatment with valproate and was successfully treated with levocarnitine. We discuss this patient and review the literature regarding the use of levocarnitine in similar patients.

Original languageEnglish
Pages (from-to)690-691
Number of pages2
JournalJournal of Clinical Neuroscience
Issue number4
Publication statusPublished - 2014


  • Encephalopathy
  • Hyperammonemia
  • Levocarnitine
  • Valproic acid

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

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