Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons

S. Taverna; M. Mantegazza; S. Franceschetti; G. Avanzini

doi:10.1016/S0920-1211(98)00060-6

Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons

S. Taverna, M. Mantegazza, S. Franceschetti, G. Avanzini

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of valproate (VPA) on Na⁺ currents (INa), was studied by means of voltage clamp recordings using whole-cell patch clamp configuration in 21 acutely dissociated neocortical neurons. Concentrations of VPA up to 200 μM failed to induce any detectable decrease in fast INa (I(Naf)), but the persistent fraction (I(NAP)) was significantly reduced by low VPA concentrations (10-30 μM), corresponding to the lower values of the 'therapeutic' range in epileptic patients. Since it is known that I(NaP) critically regulates the firing properties of pyramidal neurons, it is suggested that the anticonvulsant effectiveness of VPA is mainly due to its effect on I(Nap).

Original language	English
Pages (from-to)	304-308
Number of pages	5
Journal	Epilepsy Research
Volume	32
Issue number	1-2
DOIs	https://doi.org/10.1016/S0920-1211(98)00060-6
Publication status	Published - Sep 1 1998

Keywords

Sodium current
Valproate
Voltage clamp

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health
Neurology

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10.1016/S0920-1211(98)00060-6

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abstract = "The effect of valproate (VPA) on Na+ currents (INa), was studied by means of voltage clamp recordings using whole-cell patch clamp configuration in 21 acutely dissociated neocortical neurons. Concentrations of VPA up to 200 μM failed to induce any detectable decrease in fast INa (I(Naf)), but the persistent fraction (I(NAP)) was significantly reduced by low VPA concentrations (10-30 μM), corresponding to the lower values of the 'therapeutic' range in epileptic patients. Since it is known that I(NaP) critically regulates the firing properties of pyramidal neurons, it is suggested that the anticonvulsant effectiveness of VPA is mainly due to its effect on I(Nap).",

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T1 - Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons

AU - Taverna, S.

AU - Mantegazza, M.

AU - Franceschetti, S.

AU - Avanzini, G.

PY - 1998/9/1

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N2 - The effect of valproate (VPA) on Na+ currents (INa), was studied by means of voltage clamp recordings using whole-cell patch clamp configuration in 21 acutely dissociated neocortical neurons. Concentrations of VPA up to 200 μM failed to induce any detectable decrease in fast INa (I(Naf)), but the persistent fraction (I(NAP)) was significantly reduced by low VPA concentrations (10-30 μM), corresponding to the lower values of the 'therapeutic' range in epileptic patients. Since it is known that I(NaP) critically regulates the firing properties of pyramidal neurons, it is suggested that the anticonvulsant effectiveness of VPA is mainly due to its effect on I(Nap).

AB - The effect of valproate (VPA) on Na+ currents (INa), was studied by means of voltage clamp recordings using whole-cell patch clamp configuration in 21 acutely dissociated neocortical neurons. Concentrations of VPA up to 200 μM failed to induce any detectable decrease in fast INa (I(Naf)), but the persistent fraction (I(NAP)) was significantly reduced by low VPA concentrations (10-30 μM), corresponding to the lower values of the 'therapeutic' range in epileptic patients. Since it is known that I(NaP) critically regulates the firing properties of pyramidal neurons, it is suggested that the anticonvulsant effectiveness of VPA is mainly due to its effect on I(Nap).

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KW - Valproate

KW - Voltage clamp

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Valproate selectively reduces the persistent fraction of Na+ current in neocortical neurons

Abstract

Keywords

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