At 21 yr old white male had both an intermittent acute porphyria (IAP) and a long standing post-traumatic focal epilepsy. Most anticonvulsivant drugs apparently adversely affected both the clinical and biomedical parameters of IAP. Significant clinical improvement of the porphyria followed withdrawal of phenobarbital (PB) and carbamazepine (CBZ). Sodium valproate (VPA) appeared to be a safe drug in IAP and approximately as effective as PB for seizure control in our patient. Moreover, while the apparent plasma half life (T 1/2) of CBZ and PB were prolonged in our patient, VPA T 1/2 did not differ from those reported in the literature. It was apparent, therfore, also in regard to our findings with CBZ and VPA elimination, that VPA could be a reasonable solution to the therapeutic problem of a chronic seizure control in IAP.
|Translated title of the contribution||Valproate sodium in treatment of epilepsy associated with acute intermittent porphyria|
|Number of pages||6|
|Journal||Rivista di Neurobiologia|
|Publication status||Published - 1981|
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