Value by positron emission tomography/computed tomography as a prognostic variable in metastatic breast cancer

Patrick G. Morris, Gary A. Ulaner, Anne Eaton, Maurizio Fazio, Komal Jhaveri, Sujata Patil, Laura Evangelista, Joseph Y. Park, Cristian Serna-Tamayo, Jane Howard, Steven Larson, Clifford A. Hudis, Heather L. McArthur, Maxine S. Jochelson

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In this retrospective, single-institution study, the authors examine the maximum standardized uptake value (SUVmax) on positron emission tomography/computed tomography (PET/CT) images as a prognostic variable in patients with newly diagnosed metastatic breast cancer (MBC). Methods: Patients with ≥1 metastatic lesion on PET/CT images that were obtained within 60 days of their MBC diagnosis between January 1, 2001 and December 31, 2008 were included. Patients were excluded if they had received chemotherapy ≤30 days before the PET/CT images were obtained. Electronic medical reports were reviewed to determine the SUVmax and overall survival. Because of intraindividual variation in the SUV by body site, separate analyses were conducted by metastatic site. Relationships between site-specific PET/CT variable tertiles and overall survival were assessed using Cox regression; hazard ratios for the highest tertile versus the lowest tertile were reported. Results: In total, 253 patients were identified, and their median age was 57 years (range, 27-90 years). Of these, 152 patients (60%) died, and the median follow-up was 40 months. On univariate analysis, SUVmax tertile was strongly associated with overall survival in patients who had bone metastases (N = 141; hazard ratio, 3.13; 95% confidence interval, 1.79-5.48; P

Original languageEnglish
Pages (from-to)5454-5462
Number of pages9
JournalCancer
Volume118
Issue number22
DOIs
Publication statusPublished - Nov 15 2012

Keywords

  • maximum standardized uptake value
  • metastatic breast cancer
  • overall survival
  • positron emission tomography/computed tomography
  • prognosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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