Value of integrated PET/CT for lesion localisation in cancer patients: A comparative study

Ettore Pelosi, Cristina Messa, Sandro Sironi, Maria Picchio, Claudio Landoni, Valentino Bettinardi, Luigi Gianolli, Alessandro Del Maschio, Maria Carla Gilardi, Ferruccio Fazio

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to retrospectively compare the value of integrated PET/CT and separate PET plus morphological imaging studies for lesion localisation in cancer patients. Two different series of consecutive patients who had previously been treated for neoplastic disease were considered. One series consisted of 105 patients who had undergone [18F] fluorodeoxyglucose (FDG) PET/CT (n=70) or [11C]choline PET/CT (n=35) studies (PET/CT group). The other series comprised 105 patients who had undergone FDG PET scan (n=70) or [11C]choline PET scan (n=35) alone; in this series, PET findings were correlated with the results of morphological imaging (MI) studies, i.e. CT (n=92) or MR imaging (n=13) (PET+MI group). Regions of abnormal tracer uptake at PET scanning were classified as ambiguous or unambiguous depending on their precise anatomical localisation. A total of 207 and 196 lesions were found in the PET/CT and PET+MI groups, respectively. The difference in terms of number of lesions per patient detected with the two imaging protocols was not statistically significant (P=0.718). When analysis of lesion localisation was performed, there were 7/207 (3.4%) and 30/196 (15.3%) ambiguous lesions in the PET/CT and PET+MI groups, respectively. The number of ambiguous lesions was significantly higher in the PET+MI group than in the PET/CT group (χ2=15.768, P11C]choline PET/CT studies was similar to that observed in [18F]FDG studies. In cancer patients, PET/CT shows higher diagnostic accuracy for lesion localisation than PET plus morphological imaging studies performed independently. This result does not seem to be affected by the type of tracer used.

Original languageEnglish
Pages (from-to)932-939
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume31
Issue number7
Publication statusPublished - Jul 2004

Keywords

  • Choline
  • Comparative study
  • FDG
  • Lesion localisation
  • PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Fingerprint

Dive into the research topics of 'Value of integrated PET/CT for lesion localisation in cancer patients: A comparative study'. Together they form a unique fingerprint.

Cite this