Value of spirometric investigations in amyotrophic lateral sclerosis

M. Poloni, S. A. Mento, C. Mascherpa, M. Ceroni

Research output: Contribution to journalArticle


The respiratory function has been studied in 37 patients with ALS. 15 of them (5 till death) were followed with serial spirometric tests. The data, as a whole, show a diminution of vital capacity, a diminution of forced expiratory volume per second, an increase of the residual volume and of the Motley index; blood gas analysis showed no significant alterations apart from slight hypoxemia. Patients with bulbar ALS presented marked abnormalities of the spirometric and blood gas analysis parameters. In the cases followed with serial spirometric tests VC, Motley index and FEV1gradually deteriorated as the disease advanced. In the deceased patients a sudden and serious aggravation of these values occurred. This was especially true for FEV1and Motley index during the 3 months preceding death. The variations in residual volume were less indicative. Finally, the influence of smoking and of pulmonary and bronchial pathology, present or past, was not significant.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalItalian Journal of Neurological Sciences
Issue number1
Publication statusPublished - Apr 1983


  • Amyotrophic lateral sclerosis
  • pulmonary volumes
  • respiratory complications
  • spirometry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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