Variability comparison of simultaneous brain near-infrared spectroscopy and functional magnetic resonance imaging during visual stimulation

Ludovico Minati, Elisa Visani, Nick G. Dowell, Nick Medford, Hugo D. Critchley

Research output: Contribution to journalArticle

Abstract

Brain near-infrared spectroscopy (NIRS) is emerging as a potential alternative to functional magnetic resonance imaging (fMRI). To date, no study has explicitly compared the two techniques in terms of measurement variability, a key parameter dictating attainable statistical power. Here, NIRS and fMRI were simultaneously recorded during event-related visual stimulation. Inter-subject coefficients of variation (CVs) for peak response amplitude were considerably larger for NIRS than fMRI, but inter-subject CVs for response latency and intra-subject CVs for response amplitude were overall comparable. Our results may represent an optimistic estimate of the CVs of NIRS measurements, as optode positioning was guided by structural MRI, which is normally unavailable. We concluded that fMRI may be preferable to NIRS for group comparisons, but NIRS is equally powerful when comparing conditions within participants. The discrepancy between inter- and intra-subject CVs is likely related to variability in head anatomy and tissue properties, which may be better accounted for by emerging NIRS technology.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalJournal of Medical Engineering and Technology
Volume35
Issue number6-7
DOIs
Publication statusPublished - Aug 2011

Keywords

  • Coefficients of variation (CVs)
  • Functional magnetic resonance imaging (fMRI)
  • Measurement variability
  • Near-infrared spectroscopy (NIRS)
  • Visual stimulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine(all)

Fingerprint Dive into the research topics of 'Variability comparison of simultaneous brain near-infrared spectroscopy and functional magnetic resonance imaging during visual stimulation'. Together they form a unique fingerprint.

  • Cite this