Variability in individual response to various doses of omeprazole - Implications for antiulcer therapy

Vincenzo Savarino, Giuseppi Sandro Mela, Patrizia Zentilin, Patrizia Cutela, Maria Raffaella Mele, Sergio Vigneri, Guido Celle

Research output: Contribution to journalArticlepeer-review

Abstract

This study was carried out in order to perform a combined prospective assessment of the individual pharmacodynamic response and of duodenal ulcer healing in patients treated with three different doses of omeprazole. Ninety-nine patients with endoscopically proven duodenal ulcers were subdivided into three parallel groups of 33 cases, who were randomly assigned to receive orally at 0800 hr, in single blind fashion, either 10 mg, 20 mg, or 40 mg of omeprazole. All of them underwent continuous intragastric pH monitoring both in basal conditions and on the fifth day of each dose regimen; ulcer healing was then assessed endoscopically after four weeks of treatment. All three doses of omeprazole caused pH values to increase significantly (P

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalDigestive Diseases and Sciences
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 1994

Keywords

  • duodenal ulcer
  • omeprazole
  • pH monitoring
  • ulcer healing

ASJC Scopus subject areas

  • Gastroenterology

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