Variability in laboratory parameters used for management of Cushing’s syndrome

Francesca Pecori Giraldi, Alberto G. Ambrogio

Research output: Contribution to journalArticlepeer-review


The progress in assay methodology, from the use of radioactive tracers to chemiluminescent signals, from competitive to chromatographic techniques and from serum or urine to saliva has considerably impacted on hormonal measurements. The clinician now may choose among multiple tests but the inherent variability in cortisol and ACTH secretion, coupled to lack of harmonization among assay procedures and normal ranges mandates careful interpretation of any result. The present review will examine factors which affect interpretation of cortisol and ACTH measurements and their impact on tests used for management of Cushing’s syndrome.

Original languageEnglish
Pages (from-to)580-589
Number of pages10
Issue number3
Publication statusPublished - Dec 1 2015


  • ACTH
  • Assay
  • Cortisol
  • Cushing’s disease
  • Cushing’s syndrome
  • Diagnosis

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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