Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population

M. A. Ferroni, G. Marchi, E. Sansone, P. Romeo, P. C. Giulianotti, A. Pietrabissa, F. Mosca, G. M. Pacifici

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective. The polymorphism of erythrocyte thiopurine methyltransferase (TPMT) is genetically regulated as an autosomal codominant trait, and so should be congenital. Results. We tested this hypothesis by measuring TPMT activity in erythrocyte preparations from adults and newborns and observed polymorphic distribution of TPMT activity in the adult and newborn erythrocytes. The activity of TPMT was higher in red cells from the newborns than adults. The frequency distribution of TPMT activity was also investigated in the liver and kidney. In the kidney, TPMT activity fell into two subgroups, whereas in the liver the distribution pattern was more complex. The activity of TPMT in erythrocytes and liver from the same subject was correlated, but the values of only half the cases fell within the 95% confidence limits, suggesting that the control of hepatic and/or erythrocyte TPMT is multifactorial.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalEuropean Journal of Clinical Pharmacology
Volume51
Issue number1
DOIs
Publication statusPublished - 1996

Fingerprint

thiopurine methyltransferase
6-Mercaptopurine
Methylation
Erythrocytes
Kidney
Liver
Population

Keywords

  • 6-Mercaptopurine
  • Adults
  • Erythrocytes
  • Kidney
  • Liver
  • Newborns
  • Polymorphism
  • Thiopurine methyltransferase

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population. / Ferroni, M. A.; Marchi, G.; Sansone, E.; Romeo, P.; Giulianotti, P. C.; Pietrabissa, A.; Mosca, F.; Pacifici, G. M.

In: European Journal of Clinical Pharmacology, Vol. 51, No. 1, 1996, p. 23-29.

Research output: Contribution to journalArticle

Ferroni, M. A. ; Marchi, G. ; Sansone, E. ; Romeo, P. ; Giulianotti, P. C. ; Pietrabissa, A. ; Mosca, F. ; Pacifici, G. M. / Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population. In: European Journal of Clinical Pharmacology. 1996 ; Vol. 51, No. 1. pp. 23-29.
@article{241f9e17092944d6a8583e94311b1c26,
title = "Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population",
abstract = "Objective. The polymorphism of erythrocyte thiopurine methyltransferase (TPMT) is genetically regulated as an autosomal codominant trait, and so should be congenital. Results. We tested this hypothesis by measuring TPMT activity in erythrocyte preparations from adults and newborns and observed polymorphic distribution of TPMT activity in the adult and newborn erythrocytes. The activity of TPMT was higher in red cells from the newborns than adults. The frequency distribution of TPMT activity was also investigated in the liver and kidney. In the kidney, TPMT activity fell into two subgroups, whereas in the liver the distribution pattern was more complex. The activity of TPMT in erythrocytes and liver from the same subject was correlated, but the values of only half the cases fell within the 95{\%} confidence limits, suggesting that the control of hepatic and/or erythrocyte TPMT is multifactorial.",
keywords = "6-Mercaptopurine, Adults, Erythrocytes, Kidney, Liver, Newborns, Polymorphism, Thiopurine methyltransferase",
author = "Ferroni, {M. A.} and G. Marchi and E. Sansone and P. Romeo and Giulianotti, {P. C.} and A. Pietrabissa and F. Mosca and Pacifici, {G. M.}",
year = "1996",
doi = "10.1007/s002280050155",
language = "English",
volume = "51",
pages = "23--29",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Variability in the rate of 6-mercaptopurine methylation in the erythrocytes, liver and kidney in an Italian population

AU - Ferroni, M. A.

AU - Marchi, G.

AU - Sansone, E.

AU - Romeo, P.

AU - Giulianotti, P. C.

AU - Pietrabissa, A.

AU - Mosca, F.

AU - Pacifici, G. M.

PY - 1996

Y1 - 1996

N2 - Objective. The polymorphism of erythrocyte thiopurine methyltransferase (TPMT) is genetically regulated as an autosomal codominant trait, and so should be congenital. Results. We tested this hypothesis by measuring TPMT activity in erythrocyte preparations from adults and newborns and observed polymorphic distribution of TPMT activity in the adult and newborn erythrocytes. The activity of TPMT was higher in red cells from the newborns than adults. The frequency distribution of TPMT activity was also investigated in the liver and kidney. In the kidney, TPMT activity fell into two subgroups, whereas in the liver the distribution pattern was more complex. The activity of TPMT in erythrocytes and liver from the same subject was correlated, but the values of only half the cases fell within the 95% confidence limits, suggesting that the control of hepatic and/or erythrocyte TPMT is multifactorial.

AB - Objective. The polymorphism of erythrocyte thiopurine methyltransferase (TPMT) is genetically regulated as an autosomal codominant trait, and so should be congenital. Results. We tested this hypothesis by measuring TPMT activity in erythrocyte preparations from adults and newborns and observed polymorphic distribution of TPMT activity in the adult and newborn erythrocytes. The activity of TPMT was higher in red cells from the newborns than adults. The frequency distribution of TPMT activity was also investigated in the liver and kidney. In the kidney, TPMT activity fell into two subgroups, whereas in the liver the distribution pattern was more complex. The activity of TPMT in erythrocytes and liver from the same subject was correlated, but the values of only half the cases fell within the 95% confidence limits, suggesting that the control of hepatic and/or erythrocyte TPMT is multifactorial.

KW - 6-Mercaptopurine

KW - Adults

KW - Erythrocytes

KW - Kidney

KW - Liver

KW - Newborns

KW - Polymorphism

KW - Thiopurine methyltransferase

UR - http://www.scopus.com/inward/record.url?scp=0029782591&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029782591&partnerID=8YFLogxK

U2 - 10.1007/s002280050155

DO - 10.1007/s002280050155

M3 - Article

C2 - 8880047

AN - SCOPUS:0029782591

VL - 51

SP - 23

EP - 29

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 1

ER -