Variabilità nelle misure di efficacia per la malattia di Alzheimer

Translated title of the contribution: Variability of efficacy measures in Alzheimer's disease

Massimo Musicco, Carla Pettenati, Carlo Caltagirone

Research output: Contribution to journalArticlepeer-review


The efficacy of medical interventions is their capacity of inducing positive modifications of the natural history of diseases. The natural history of dementia is marked by specific events related to the cognitive and functional decline, but their occurrence is poorly predictable in individual patients being highly variable from patient to patient. For this reason it is difficult that the modest efficacy of available interventions for dementia, or their entity measured by clinical scales, may be perceived in clinical practice or in observational studies. Moreover in randomized clinical studies, the effect of this variability, in analogy to misclassification of exposition and/or disease in case control or cohort epidemiological studies, is that of an underestimation of the true efficacy of interventions.

Translated title of the contributionVariability of efficacy measures in Alzheimer's disease
Original languageItalian
Pages (from-to)87-91
Number of pages5
JournalAnnali dell'Istituto Superiore di Sanita
Issue number1
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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